
- 276 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
About this book
Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances intreatment, the disease remains associated withpoorsurvival andresistanceto cytotoxic and targeted therapies.Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa.- Tackles the topic of resistance from a broader perspective, including, but not limited to, the role of the extracellular matrix and cancer stem cells in therapy resistance- Creates understanding on how to develop novel therapies that specifically target CSCs to eliminate the regenerating capacity of the tumor and overcome therapy resistance- Helps in identifying novel molecular biomarkers and potential therapeutic targets pertaining to the tumor microenvironment to overcome therapy resistance- Provides a general view of the main pathways involved in PCa progression that will aid in understanding the mechanisms responsible for chemotherapy resistance
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Information
Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Cover Image Insert
- Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy”
- About the Series Editor
- Aims and Scope of Volume
- About the Volume Editor
- Preface
- Contributors
- Chapter 1 Prostate gland anatomy and hormonal factors contributing to cancer development
- Chapter 2 Role of tumor microenvironment in prostate cancer therapy resistance
- Chapter 3 Androgen receptor-dependent mechanisms mediating therapy resistance in prostate cancer
- Chapter 4 Epigenetic changes driving therapy resistance in prostate cancer
- Chapter 5 Role of cancer stem cells in prostate cancer therapy resistance
- Chapter 6 Resistance to taxane chemotherapies in prostate cancer
- Chapter 7 Resistance of prostate cancer to topoisomerase inhibitors
- Chapter 8 Resistance of prostate cancer to kinase inhibitors
- Chapter 9 Radioresistance mechanisms in prostate cancer
- Chapter 10 Immunotherapeutic strategies and immunotherapy resistance in prostate cancer
- Chapter 11 Overcoming resistance in prostate cancer with targeted and small molecule-based therapies
- Chapter 12 Novel treatment strategies to overcome resistance in prostate cancer
- Index