pH Deregulation as the Eleventh Hallmark of Cancer
eBook - ePub

pH Deregulation as the Eleventh Hallmark of Cancer

  1. 200 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

pH Deregulation as the Eleventh Hallmark of Cancer

About this book

pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment. pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer. - Proposes that pH deregulation should be considered as an independent hallmark of cancer from metabolic reprogramming due to its impact on all other hallmarks (based on seminal work of Hanahan and Weinberg) - Explains basic issues of cancer pH deregulation and its consequences in a simple and concise manner - Discusses the subject from the start with very elementary concepts on pH and pH regulation to help readers understand key concepts without proper background - Presents key concepts through original illustrations and table for easy comprehension

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Yes, you can access pH Deregulation as the Eleventh Hallmark of Cancer by Tomas Koltai,Larry Fliegel,Stephan J. Reshkin,Fatima Baltazar,Rosa Angela Cardone,Khalid Omer Alfarouk,Julieta Afonso in PDF and/or ePUB format, as well as other popular books in Business & Business Intelligence. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Academic Press
Year
2023
Print ISBN
9780443154614
eBook ISBN
9780443154621
Topic
Business
Subtopic
Business Intelligence
Index
Business

Table of contents

  1. pH Deregulation as the Eleventh Hallmark of Cancer
  2. Cover
  3. Title Page
  4. Copyright
  5. Table of Contents
  6. Dedication
  7. Acknowledgment
  8. Chapter 1 pH Regulation and metabolism: Basic concepts
  9. Chapter 2 The pH gradient in cancer: pH deregulation
  10. Chapter 3 The pHtome
  11. Chapter 3.1 Na+/H+ exchangers (NHEs)
  12. Chapter 3.2 Voltage gated sodium channels (VGSCs)
  13. Chapter 3.3 Carbonic anhydrases (CAs)
  14. Chapter 3.4 The sodium bicarbonate cotransporter (NBC) family
  15. Chapter 3.5 Monocarboxylate transporters (MCTs) and lactate
  16. Chapter 3.6 The vacuolar type-ATPase proton pump
  17. Chapter 3.7 Voltage gated proton channel (Hv1)
  18. Chapter 4 Coordinated action of the pHtome: Integrating the cancer pH process
  19. Chapter 5 How pH deregulation favors the hallmarks of cancer
  20. Chapter 6 Deregulated pH: Therapeutic implications and treatment
  21. Chapter 7 Cancer metabolism and its interplay with pH
  22. Chapter 8 pH and drug resistance
  23. Chapter 9 Membrane proton sensing potentiates the pro-tumoral effects of extracellular acidity
  24. Chapter 10 Final words
  25. Index