Multiscale Biomechanical Modeling of the Brain

Mark F. Horstemeyer, Raj K. Prabhu

• Publisher: Academic Press
• Year: 2021
• Print ISBN: 9780128181447
• eBook ISBN: 9780128181454
• Topic: Technology & Engineering
• Subtopic: Engineering General
• Index: Technology & Engineering

Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels. - Presents concepts in a theoretical and thermodynamic framework for each length scale - Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model - Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems

Table of contents

• Title of Book
• Cover image
• Title page
• Table of Contents
• Copyright
• Table of Contents
• Contributors
• Preface
• Chapter 1 The multiscale nature of the brain and traumatic brain injury
• Chapter 2 Introduction to multiscale modeling of the human brain
• Chapter 3 Density functional theory and bridging to classical interatomic force fields
• Chapter 4 Modeling nanoscale cellular structures using molecular dynamics
• Chapter 5 Microscale mechanical modeling of brain neuron(s) and axon(s)
• Chapter 6 Mesoscale finite element modeling of brain structural heterogeneities and geometrical complexities
• Chapter 7 Modeling mesoscale anatomical structures in macroscale brain finite element models
• Chapter 8 A macroscale mechano-physiological internal state variable (MPISV) model for neuronal membrane damage with subscale microstructural effects
• Chapter 9 MRE-based modeling of head trauma
• Chapter 10 Robust concept exploration of driver’s side vehicular impacts for human-centric crashworthiness
• Chapter 11 Development of a coupled physical–computational methodology for the investigation of infant head injury
• Chapter 12 Experimental data for validating the structural response of computational brain models
• Chapter 13 A review of fluid flow in and around the brain, modeling, and abnormalities
• Chapter 14 Resonant frequencies of a human brain, skull, and head
• Chapter 15 State-of-the-art of multiscale modeling of mechanical impacts to the human brain
• Index