Epigenetic Cancer Therapy
eBook - ePub

Epigenetic Cancer Therapy

  1. 772 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Epigenetic Cancer Therapy

About this book

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs - Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution - Features chapter contributions from leading experts in the field

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Yes, you can access Epigenetic Cancer Therapy by Steven Gray in PDF and/or ePUB format, as well as other popular books in Medicine & Oncology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Academic Press
Year
2023
eBook ISBN
9780323917155
Edition
2
Topic
Medicine
Subtopic
Oncology

Table of contents

  1. Epigenetic Cancer Therapy
  2. Chapter 1 Introduction
  3. Chapter 2 Methylation and hydroxymethylation in cancer
  4. Chapter 3 Writers, erasers, and readers of DNA and histone methylation marks
  5. Chapter 4 Oncohistones
  6. Chapter 5 microRNA, epi-microRNA, and cancer
  7. Chapter 6 Long noncoding RNA in human cancers: to be or not to be, that is the question
  8. Chapter 7 The emerging roles of epitranscriptomic marks in cancer
  9. Chapter 8 Epigenomic profiling at genome scale: from assays and analysis to clinical insights
  10. Chapter 9 Environmental pollution, epigenetics, and cancer
  11. Chapter 10 Synthetic biology and cell engineering—deriving new insights into cancer epigenetics
  12. Chapter 11 Epigenetic targeted therapies in hematological malignancies
  13. Chapter 12 Epigenetic therapy in lung cancer
  14. Chapter 13 Breast cancer epigenetics
  15. Chapter 14 Therapeutic applications of the prostate cancer epigenome
  16. Chapter 15 Neuroblastoma
  17. Chapter 16 Epigenetic therapies—update on lysine methyltransferase/PRC complex inhibitors
  18. Chapter 17 Inhibitors of Jumonji-C domain-containing histone demethylases
  19. Chapter 18 Emerging epigenetic therapies—lysine acetyltransferase inhibitors
  20. Chapter 19 Epigenetic therapies: histone deacetylases
  21. Chapter 20 Epigenetic intratumoral heterogeneity
  22. Chapter 21 Challenges for single-cell epigenetic analysis
  23. Chapter 22 Epigenetics of cisplatin resistance
  24. Chapter 23 Emerging epigenetic therapies: protein arginine methyltransferase inhibitors
  25. Chapter 24 Personalized epigenetic therapy—chemosensitivity testing
  26. Chapter 25 Epigenetic profiling in cancer: triage, prognosis, and precision oncology
  27. Chapter 26 Epigenetic priming—fact or falacy?
  28. Chapter 27 CRISPR, epigenetics, and cancer
  29. Index