Nitric Oxide in Health and Disease

Therapeutic Applications in Cancer and Inflammatory Disorders

Lucia Morbidelli, Benjamin Bonavida, Jordi Muntané

• Publisher: Academic Press
• Year: 2023
• Print ISBN:
  9780443133428
• eBook ISBN:
  9780443133435
• Topic: Business
• Subtopic: Business intelligence
• Index: Business

Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. - Provides updated reviews on the chemistry and signaling of newly derived therapeutic nitric oxide (NO) donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities - Discusses the application of NO in monotherapy or in combination with conventional therapies in a variety of cancers and inflammatory diseases - Encompasses real-world examples of recent research related to NO and cancer

Table of contents

• Cover
• Front Matter
• Table of Contents
• Copyright
• Contributors
• About the Editors
• Preface
• Highlights of the II international conference “therapeutic applications of nitric oxide in cancer and inflammatory-related diseases”
• Conference Program
• List of Illustrations
• List of Tables
• Chapter 1 : Nitric oxide and derivatives: Molecular insights and translational opportunities
• Chapter 2 : Biomedical applications of polymeric nitric oxide (NO) donors
• Chapter 3 : Therapeutic potential for coxib-nitric oxide releasing hybrids in cancer treatment
• Chapter 4 : Targeting dimethylarginine dimethylaminohydrolase 1 to suppress vasculogenic mimicry in breast cancer: Current evidence and future directions
• Chapter 5 : Cancer stem cells and nitric oxide
• Chapter 6 : Inducible nitric oxide synthase 2 (NOS2) and antitumor γδ-T cells
• Chapter 7 : The regulation of the programmed death ligand 1 (PD-L1) by nitric oxide in breast cancer: Immunotherapeutic implication
• Chapter 8 : Pepper fruit, as a nutraceutical food, shows antiproliferative activity against tumor cells and it is potentiatied by nitric oxide (NO)
• Chapter 9 : Nitric oxide (NO) donors in kidney damage and diseases
• Chapter 10 : Nitric oxide resistance in type 2 diabetes: Potential implications of HNO donors
• Chapter 11 : Inhaled nitric oxide (iNO) administration in intubated and nonintubated patients: Delivery systems, interfaces, dose administration, and monitoring techniques
• Chapter 12 : Inhaled nitric oxide (iNO): Clinical applications in critical care medicine, delivery devices, and measuring techniques
• Chapter 13 : Mechanistic insights on the role of nitric oxide in ischemia-reperfusion injury
• Chapter 14 : Effect of nitric oxide inhibitors in retinitis pigmentosa
• Chapter 15 : Advances in the discovery of novel agents for the treatment of glaucoma: The role of nitric oxide donors
• Conclusions and future perspectives
• Index
• A