Prostate Cancer Metabolism

From Biochemistry to Therapeutics

Tomas Koltai, Stephan J. Reshkin, Fatima Baltazar, Larry Fliegel

• Publisher: Academic Press
• Year: 2021
• Print ISBN:
  9780323905282
• eBook ISBN:
  9780323905510
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. - Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice - Discusses new drugs and nutraceuticals with a metabolism-centered approach - Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Preface
• Acknowledgment
• Abbreviations used in this book
• Chapter 1. Introductory words: cell metabolism and systems biology
• Chapter 2. Introduction to prostate cancer metabolism and treatment with nonconventional drugs
• Chapter 3a. The conductors of the metabolic orchestra: part I
• Chapter 3b. Phosphatase and tensin homolog deleted in chromosome 10: another metabolic regulator in prostate cancer?
• Chapter 4. Lipid metabolism part I: an overview
• Chapter 5. Lipid metabolism part II: sphingolipids and ceramides
• Chapter 6. Fatty acid synthesis and prostate cancer
• Chapter 7. Cholesterol metabolism in prostate cancer
• Chapter 8. Glutamine metabolism in prostate cancer
• Chapter 9. Carbohydrate metabolism in prostate cancer
• Chapter 10. pH and electrolytes metabolism in prostate cancer
• Chapter 11. Iron metabolism in prostate cancer
• Chapter 12. Androgen metabolism in castration-resistant prostate cancer
• Chapter 13. Summary, discussion, and conclusions
• Index