eBook - ePub
Clinical Studies and Therapies in Parkinson's Disease
Translations from Preclinical Models
- 306 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
Clinical Studies and Therapies in Parkinson's Disease
Translations from Preclinical Models
About this book
More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson's disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson's disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease.Clinical Studies and Therapies in Parkinson's Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book's discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine.
- Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms
- Analyzes preclinical models of Parkinson's disease therapies based on exogenous neurotoxins and why they have failed
- Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins
- Proposes a more physiological model directly related to the metabolism of dopaminergic neurons
- Provides the basic concepts and mechanisms of dopamine metabolism
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Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access Clinical Studies and Therapies in Parkinson's Disease by Juan Segura-Aguilar in PDF and/or ePUB format, as well as other popular books in Ciencias biológicas & Farmacología. We have over one million books available in our catalogue for you to explore.
Information
Table of contents
- Clinical Studies and Therapies in Parkinson’s Disease
- Chapter 1 Parkinson’s disease
- Chapter 2 Parkinson’s pharmacological therapy
- Chapter 3 Dopamine synthesis
- Chapter 4 Dopamine storage and release
- Chapter 5 Dopamine oxidative deamination
- Chapter 6 Dopamine methylation
- Chapter 7 Dopamine oxidation to neuromelanin and neurotoxic metabolites
- Chapter 8 Neuroprotective mechanisms against dopamine oxidation-dependent neurotoxicity
- Chapter 9 Exogenous neurotoxins as a preclinical model for Parkinson’s disease
- Chapter 10 Preclinical models based on genetic mutations associated with the familial form of Parkinson’s disease
- Chapter 11 Preclinical models based on endogenous neurotoxins
- Chapter 12 Conclusions
- Index