Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics

Sunny Ohia, Najam Sharif

• Publisher: Academic Press
• Year: 2022
• Print ISBN: 9780128192917
• eBook ISBN: 9780128192924
• Topic: Medicine
• Subtopic: Oncology

Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics provides a review of the basic anatomy, physiology, biochemistry and pathology of the eye with a focus drug therapy, drug delivery and use of therapeutic medical miniature devices. An understanding of the pharmacological actions of drugs acting on the eye requires the student and health care practitioner to learn additional principles in basic and clinical sciences that are unique to this organ. As a sensory organ, the eye is relatively inaccessible to the systemic circulation due to the blood-vitreous, blood-aqueous and blood-retinal barriers. Consequently, the administration of drugs for therapeutic effects in the eye necessitates an understanding of physico-chemical properties of the molecules and pharmacokinetic principles involved in the access to its site of action via topical, intracameral and intravitreal administration. This book includes information on the general principles of pharmacokinetics and pharmacodynamics of drugs as it pertains to the eye and in combating ocular disorders and diseases. Using a disease-themed approach, the book discusses basic and clinical pharmacological principles involved in the therapy of these diseases including the ocular side effect of systemically-administered drugs, drugs used in ophthalmic surgery and miscellaneous agents, the therapeutic utility of biologics, drug conjugates, combination products, gene and cellular therapy are also covered. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics is useful as a primary and secondary source of reference for up-to-date information about the pharmacological mechanisms of action, pharmacokinetics, side effects, drug-drug interactions and therapeutic indications of drugs for pharmacologists, pharmaceutical scientists, students in the health care disciplines (nursing, pharmacy, optometry, medical), and practitioners in optometry and ophthalmology. - Explains the mechanisms of action, side-effects and therapeutic uses of drugs, biologics, miniature devices, gene and cellular therapies for the eye - Provides a comprehensive review of the anatomy, physiology, biochemistry, pharmacology, microbiology, genetics and pathology of parts of the eye involved in drug therapy to combat eye disorders and diseases - Explores the pharmacological and clinical basis of drugs, drug conjugates, combination products used in the treatment of anterior and posterior segment diseases

Table of contents

• Title of Book
• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• List of contributors
• Preface
• Acknowledgments
• Chapter 1 The eye as a target for drugs and other treatment modalities
• Subchapter 1.2 Ocular biochemistry
• Subchapter 1.3 Physiology
• Subchapter 1.4 Receptors, ion channels, and signal transduction pathways as targets for drug intervention to mitigate ocular diseases
• Chapter 2 Ocular autonomic physiology and pharmacology
• Chapter 3 Ocular drug discovery and development
• Subchapter 3.2 Screening strategies for drug discovery-focus on ocular hypertension
• Subchapter 3.3 Therapeutic modality aspects in safety and efficacy of ocular drugs
• Subchapter 3.4 Investigational new drug-enabling studies for ocular and other therapeutics
• Subchapter 3.5 Preclinical ocular regulatory science—investigational new drug-enabling studies
• Subchapter 3.6 Ocular clinical regulatory sciences
• Chapter 4 Drug formulation, delivery, and ocular pharmacokinetics
• Subchapter 4.2 Ocular pharmacokinetics
• Chapter 5 Pharmaco-devices therapy for glaucoma
• Subchapter 5.2 Various forms of glaucoma and their treatments
• Subchapter 5.3 Glaucoma pharmacology
• Subchapter 5.4 Minimally invasive glaucoma surgical devices
• Subchapter 5.5 Gene therapy for ocular hypertension and glaucoma treatment
• Subchapter 5.6 Retina–brain axis and neuroprotection
• Chapter 6 Pharmacotherapy of retinal diseases
• Subchapter 6.2 Age-related macular degeneration and its treatment options
• Subchapter 6.3 Pharmacotherapy of diabetic retinopathy
• Subchapter 6.4 Inherited retinal dystrophies
• Chapter 7 Pharmacotherapy of inflammatory eye diseases
• Subchapter 7.2 Noninfectious anterior, posterior, and panuveitis and their treatments
• Chapter 8 Etiology and pharmacotherapy of ocular surface allergic diseases
• Chapter 9 Pharmacotherapy of dry eye disease and ocular pain
• Chapter 10 Pharmacotherapies for myopia and ocular refractive errors
• Subchapter 10.2 Cataracts and presbyopia
• Chapter 11 Pharmacotherapy of ocular infectious diseases
• Chapter 12 Ocular side effects of drugs administered systemically for treatment of nonocular diseases
• Chapter 13 Current and emerging techniques/technologies in ocular research and drug/device development
• Subchapter 13.2 Single-cell genetics approach in ophthalmology
• Subchapter 13.3 Muller glia-derived exosomes and their microRNA cargo–potential for glaucoma therapies
• Subchapter 13.4 Genetics and other techniques to create novel animal models for ocular research
• Subchapter 13.5 Imaging of apoptosing retinal cells for early diagnosis
• Subchapter 13.6 Optogenetic approaches to gene therapy for vision restoration in retinal degenerative diseases
• Subchapter 13.7 Multispecific biologics in opthalmology
• Subchapter 13.8 CRISPR–Cas9: current and future utilities in ocular diseases
• Subchapter 13.9 DNA methylation: its role in retinal health and diseases
• Index