Green Synthetic Approaches for Biologically Relevant Heterocycles

Volume 1: Advanced Synthetic Techniques

Goutam Brahmachari

• Publisher: Elsevier
• Year: 2021
• eBook ISBN: 9780323851305
• Edition: 2
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. - Provides fully updated coverage of the field of greener heterocycle synthesis - Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches - Presents information in an accessible style with an emphasis on sustainability

Table of contents

• Title of Book
• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• List of contributors
• Editor
• Foreword
• Preface
• Chapter 1 Green synthetic approaches for biologically relevant heterocycles: advanced synthetic techniques—an overview
• Chapter 2 High-pressure cycloaddition reactions in the synthesis of biologically relevant heterocycles
• Chapter 3 Microwave-assisted synthesis of medicinally privileged heterocycles
• Chapter 4 Application of microwave irradiation in the synthesis of P-heterocycles
• Chapter 5 Microwave-assisted multicomponent reactions as a green synthetic approach to heterocycles: special reference to Hantzsch, Biginelli, and Groebke–Blackburn–Bienayme reactions
• Chapter 6 Use of ball milling for the synthesis of biologically active heterocycles
• Chapter 7 Recent advances in photocatalytic Minisci reaction: an eco-friendly functionalization of biologically relevant heteroarenes
• Chapter 8 Recent advances for construction and late-stage diversification of indole core via C–H bond activation/functionalization
• Chapter 9 Cycloaddition reactions in ionic liquids for the synthesis of biologically relevant heterocycles
• Chapter 10 Advances in greener processes for triazole synthesis via azide-alkyne cycloaddition reactions
• Chapter 11 Employing arynes in transition-metal-free synthesis of benzo-fused five and six-membered heterocycles: an update
• Chapter 12 Multicomponent approach for the sustainable synthesis of lawsone-based heterocycles
• Chapter 13 Synthesis of biologically relevant heterocyclic skeletons under solvent-free condition
• Chapter 14 Ultrasound-promoted metal-catalyzed synthesis of heterocyclic compounds of medicinal interest
• Chapter 15 Ultrasonication under catalyst-free condition: an advanced synthetic technique toward the green synthesis of bioactive heterocycles
• Chapter 16 Self-catalytic techniques for the synthesis of biologically relevant heterocyclic scaffolds at room temperature: a recent update
• Index