Cellular Senescence in Disease
eBook - ePub

Cellular Senescence in Disease

  1. 472 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Cellular Senescence in Disease

About this book

Winner of the 2023 PROSE award in Biomedicine and Neuroscience!   Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases.  All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells.  Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities. - 2023 PROSE Awards - Winner: Category: Biomedicine and Neuroscience: Association of American Publishers - Provides a thorough introduction to Cellular Senescence - Covers all major pathologies for which cellular senescence has shown evidence of involvement - Focuses on possible therapeutic pathways - Edited and authored by worldwide experts

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Yes, you can access Cellular Senescence in Disease by Manuel Serrano,Daniel Munoz-Espin in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Cell Biology. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover
  2. Front Matter
  3. Table of Contents
  4. Copyright
  5. Contributors
  6. Foreword
  7. List of Illustrations
  8. List of Tables
  9. Chapter 1 : Cellular senescence: from old to new testament
  10. Chapter 2 : Premalignant lesions and cellular senescence
  11. Chapter 3 : Lung aging and senescence in health and disease
  12. Chapter 4 : Cell senescence in pulmonary hypertension
  13. Chapter 5 : Liver diseases fibrosis and cirrhosis
  14. Chapter 6 : Cellular senescence during aging and chronic liver diseases: mechanisms and therapeutic opportunities
  15. Chapter 7 : Kidney diseases: fibrosis
  16. Chapter 8 : Kidney diseases: transplantation
  17. Chapter 9 : Vascular diseases: atherosclerosis and atherosclerotic cardiovascular diseases
  18. Chapter 10 : Diabetes: senescence in type 1 diabetes
  19. Chapter 11 : Senescence in obesity: causes and consequences
  20. Chapter 12 : A framework for addressing senescent cell burden in the osteoarthritic knee: therapeutics, immune signaling, and the local-systemic interface
  21. Chapter 13 : Osteoporosis and bone loss
  22. Chapter 14 : Cellular senescence in neurodegenerative diseases
  23. Chapter 15 : Cell senescence is a cause of frailty
  24. Chapter 16 : Senescence as a therapeutic target: current state and future challenges
  25. Index
  26. A