Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Vijay Kumar

• Publisher: Academic Press
• Year: 2021
• Print ISBN: 9780128163641
• eBook ISBN: 9780128167342
• Topic: Ciencias biológicas
• Subtopic: Biofísica

Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. - Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth - Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases - Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations

Table of contents

• Title of Book
• Cover image
• Title page
• Table of Contents
• Front Matter
• Copyright
• Contributors
• Chapter 1 Introduction to ribosome factory, origin, and evolution of translation
• Chapter 2 Ribosome structure
• Chapter 3 rDNA gene structure, transcription, and its coregulation
• Chapter 4 Ribosome proteins—Their balanced production
• Chapter 5 Ribosome diversity
• Chapter 6 Ribosome cycle—Assembly, degradation, and recycling
• Chapter 7 Ribosomal biogenesis in eukaryotes
• Chapter 8 Ribosome biogenesis in prokaryotes
• Chapter 9 Translation—Process and control
• Chapter 10 Inhibitors of ribosome biogenesis in prokaryotes and eukaryotes
• Chapter 11 Ribosomopathies—A tree of pathologies with many roots and branches!
• Chapter 12 Ribosomal profiling—Diversity and applications
• Index