Chromatin Readers in Health and Disease

Olivier Binda, Trygve O Tollefsbol, Trygve O. Tollefsbol

• Publisher: Academic Press
• Year: 2023
• Print ISBN:
  9780128233764
• eBook ISBN:
  9780323903141
• Topic: Medicine
• Subtopic: Genetics in Medicine

Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders. - Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers - Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling - Includes chapter contributions from international leaders in the field

Table of contents

• Chromatin Readers in Health and Disease
• Cover
• Translational Epigenetics Series
• Title Page
• Table of Contents
• Copyright
• Contributors
• Preface
• Chapter 1 ADD domains—A regulatory hub in chromatin biology and disease
• Chapter 2 The BAH domain: A versatile histone modification reader
• Chapter 3 BRCT domains as chromatin readers: Structure, function, and clinical implications
• Chapter 4 The bromodomain acyl-lysine readers in human health and disease
• Chapter 5 CHROMO domain readers: A rainbow of opportunities
• Chapter 6 The MBT proteins: Methyl-lysine readers for stem cells, development, and tumors
• Chapter 7 Epigenetically decipherING the genome: A role for PHDs
• Chapter 8 Recognition of histone methylation and DNA by the PWWP domain: Mechanism and function
• Chapter 9 Spin repeats and human pathologies
• Chapter 10 Chromatin readers of the WD-repeat containing protein family
• Chapter 11 The multifunctional YEATS domain in chromatin biology
• Chapter 12 DNA methylation and reader or writer proteins: Differentiation and disease
• Chapter 13 CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins
• Index