α-Tertiary Amines en Route to Natural Products

Abdul Hameed, Mariya Al-Rashida, Muhammad Raza Shah

• Publisher: Elsevier
• Year: 2021
• Print ISBN:
  9780128222621
• eBook ISBN:
  9780128233689
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

?-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. The book covers the class of natural products bearing the ?,?-disubstituted ?-amino acid motif. Featured natural product molecules include Altemicidin, Amathaspiramide (A-F), Kaitocephalin, Lactacystin, Salinosporamide, Manzacidins (A,C), Neooxazolomycin, Sphingofungins (E,F), (1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid (ACPD), Total synthesis of cephalotaxine and related molecules, ?-amino acids based natural products, ? amino acid based natural products and Tetrodotoxin. This book is ideal for chemists working in the area of organic synthesis, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis. - Outlines synthetic strategies for natural products bearing ?-tertiary amines and ?,?-disubstituted ?-amino acid motif - Describes multistep synthetic routes that highlight key steps - Covers asymmetric and diastereoselective synthetic approaches towards targeted natural products - Illustrates multistep synthetic routes related to -amino acids based natural products and -amino acids based natural products

Table of contents

• Title of Book
• Cover image
• Title page
• Table of Contents
• Copyright
• Preface
• Chapter 1 Natural products with α-tertiary amine
• Chapter 2 Altemicidin
• Chapter 3 Amathaspiramides A–F
• Chapter 4 Cephalotaxine
• Chapter 5 Kaitocephalin
• Chapter 6 Lactacystin
• Chapter 7 Salinosporamide A
• Chapter 8 Manzacidins
• Chapter 9 Neooxazolomycin
• Chapter 10 Sphingofungins
• Chapter 11 (−)-FR901483 and TAN1251 (A-D)
• Chapter 12 Synthetic approach to the TAN1251 alkaloids
• Chapter 13 (1S,3R)-1-Aminocyclopentane-1,3-diarboxylic acid (ACPD)
• Chapter 14 Tetrodotoxin
• Abbreviations
• Index