Chemical and Biological Aspects of Pyridoxal Catalysis

Proceedings of a Symposium of the International Union of Biochemistry, Rome, October 1962

E. E. Snell, P. M. Fasella, A. Braunstein

• Publisher: Pergamon
• Year: 2013
• Print ISBN:
  9780080104232
• eBook ISBN:
  9781483152387
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Chemical and Biological Aspects of Pyridoxal Catalysis contains the proceedings of the symposium of the International Union of Biochemistry, held in Rome in October 1962. The proceedings cover the lectures, discussions, and scientific papers on the many aspects of pyridoxal biochemistry. The book presents a wide range of topics of pyridoxal biochemistry, starting with a brief review of the history of the chemistry of vitamin B6 and pyridoxal-containing systems, and their significance in the understanding of the catalytic effects of pyridoxal. Structural features of glutamic aspartic transaminase; studies on leucine decarboxylase; cleavage of cystamine by diamineoxidase; and enzymatic steps in the degradation of vitamin B6 by bacteria are also discussed. The final chapter gives a brief survey of the developments in the study of catalytic functions and biological role of PLP enzymes. Biochemists, biologists, chemists, enzymologists, pharmacologists, and physicians will find this book invaluable.

Table of contents

• Front Cover
• Chemical and Biological Aspects of Pyridoxal Catalysis
• Copyright Page
• Table of Contents
• PREFATORY NOTE
• OPENING ADDRESS
• OPENING REMARKS
• WELCOMING ADDRESS
• CHAPTER 1. NON-ENZYMATIC REACTIONS OF PYRIDOXAL AND THEIR SIGNIFICANCE
• CHAPTER 2. SCHIFF BASES OF PYRIDOXAL ANALOGS: MOLECULAR SPECIES IN SOLUTION
• CHAPTER 3. THE IMIDAZOLE–IMIDAZOLIUM ION CONCERTED GENERAL ACID, GENERAL BASE CATALYSIS OF THE TRANSAMINATION OF PYRIDOXAL BY α-AMINOPHENYLACETIC ACID
• CHAPTER 4. TRANSALDIMINATION REACTIONS OF PYRIDOXAL AND RELATED COMPOUNDS
• CHAPTER 5. REACTIONS OF PYRIDOXAL-N-METHOCHLORIDE WITH AMINO ACIDS
• CHAPTER 6. INTERMEDIATE COMPOUNDS OF NON-ENZYMIC TRANSAMINATIONS
• CHAPTER 7. NON-ENZYMIC TRANSAMINATION OF γ-AMINOBUTYRIC ACID
• CHAPTER 8. A QUANTUM-MECHANICAL INVESTIGATION OF PYRIDOXAL-DEPENDENT REACTIONS
• CHAPTER 9. THE REACTIVITY OF THE PYRIDOXAL PHOSPHATE GROUP OF GLUTAMIC ASPARTIC AMINOTRANSFERASE
• CHAPTER 10. BINARY COMPLEXES INVOLVED IN ENZYMIC TRANSAMINATION
• CHAPTER 11. STRUCTURAL FEATURES OF GLUTAMIC ASPARTIC TRANSAMINASE
• CHAPTER 12. THE ROLE OF THIOL GROUPS IN ASPARTATE–GLUTAMATE TRANSAMINASE
• CHAPTER 13. THE RESOLUTION OF ASPARTATE AMINOTRANSFERASE
• CHAPTER 14. THE DIFFERENCES BETWEEN THE GLUTAMIC OXALOACETIC APOTRANSAMINASES OF MITOCHONDRIA AND THE SUPERNATANT FRACTION OF BEEF LIVER
• CHAPTER 15. THE MECHANISM OF ENZYMATIC TRANSAMINATION
• CHAPTER 16. KINETIC STUDIES OF GLUTAMIC–ASPARTIC TRANSAMINASE (PIG HEART MUSCLE)
• CHAPTER 17. PURIFICATION AND PROPERTIES OF THE β-ASPARTIC DECARBOXYLASE OF DESULFOVIBRIO DESULFURICANS
• CHAPTER 18. α-ΚΕΤΟ ACID-ACTIVATED ENZYMATIC DECARBOXYLATION OF L-ASPARTATE TO L-ALANINE
• CHAPTER 19. STUDIES ON AMINOMALONATE
• CHAPTER 20. STUDIES ON LEUCINE DECARBOXYLASE
• CHAPTER 21. MAMMALIAN AROMATIC L-AMINO ACID DECARBOXYLASE
• CHAPTER 22. SOME ASPECTS OF AMINO ACID DECARBOXYLASE INHIBITION
• CHAPTER 23. PHOSPHOPYRIDOXAL DERIVATIVES FOR THE GLUTAMIC DECARBOXYLASE AND GLUTAMIC ASPARTIC TRANSAMINASE
• CHAPTER 24. SUR LES HYDRAZONES DE PHOSPHO-5-PYRIDOXAL, ROLE CO-ENZYMATIQUE ET STABILIT
• CHAPTER 25. THE PREDETERMINED SYNTHESIS OF INHIBITORS FOR PYRIDOXALIC ENZYMES
• CHAPTER 26. THE INVESTIGATION OF THE INTERACTION OF CYCLOSERINE AND RELATED COMPOUNDS WITH ASPARTATE–GLUTAMATE TRANSAMINASE
• CHAPTER 27. PRELIMINARY REPORT ON THE PRESENCE IN HUMAN URINE OF SUBSTANCES INFLUENCING PYRIDOXAL PHOSPHATE-DEPENDENT ENZYMES
• CHAPTER 28. INHIBITION IN VIVO ET IN VITRO DE CERTAINS ENZYMES À PYRIDOXAL PHOSPHATE (PLP) PAR L'HYDRAZIDE DE L'ACIDE ISONICOTINIQUE (INH) ET PAR LA CYCLOSERINE (CS)
• CHAPTER 29. THE IDENTITY OF CYSTEINE DESULFHYDRASE WITH CYSTATHIONASE AND MECHANISM OF CYSTEINE-CYSTINE DESULFHYDRATION
• CHAPTER 30. MECHANISMS OF SOME PYRIDOXAL PHOSPHATE POTENTIATED ELIMINATION AND REPLACEMENT REACTIONS
• CHAPTER 31. LES ENZYMES À PYRIDOXAL DANS LA SYNTHÈSE DE LA TAURINE À PARTIR DU SULFATE
• CHAPTER 32. CLEAVAGE OF CYSTAMINE BY DIAMINEOXIDASE
• CHAPTER 33. THE PURIFICATION OF HOG KIDNEY DIAMINE OXIDASE
• Chapter 34. HISTAMINASE, A PYRIDOXAL PHOSPHATE AND FLAVIN ADENINE DINUCLEOTIDE DEPENDENT ENZYME
• CHAPTER 35. STUDIES ON THE COFACTORS AND OPTICAL PROPERTIES OF HOG KIDNEY DIAMINE OXIDASE
• CHAPTER 36. PLASMA AMINE OXIDASE; A CUPRIC-PYRIDOXAL PHOSPHATE ENZYME
• CHAPTER 37. AN ADP DEPENDENT THREONINE DEHYDRASE FROM CLOSTRIDIUM TETANOMORPHUM
• CHAPTER 38. EFFECTS OF THYROID HORMONES ON DIFFERENT TYPES OF PYRIDOXAL PHOSPHATE-DEPENDENT ENZYMES OF RAT LIVER
• CHAPTER 39. VITAMIN Β6 AND TOXOPYRIMIDINE-CONVULSIONS
• CHAPTER 40. INHIBITION OF LIVER KYNURENINASE IN HYPOPHYSECTOMIZED OR ADRENALECTOMIZED RATS
• CHAPTER 41. TRYPTOPHANASE-TRYPTOPHAN SYNTHETASE RELATIONSHIP
• CHAPTER 42. ENZYMATISCH-OPTISCHE BESTIMMUNG VON PYRIDOXAL-5-PHOSPHORSÄUREESTER UND PYRIDOXAMIN-5-PHOSPHORSÄUREESTER MIT GLUTAMAT/ASPARTAT-TRANSAMINASE AUS BIERHEFE
• CHAPTER 43. THE RELATION OF VITAMIN B6 TO TRANSPORT
• CHAPTER 44. PYRIDOXAL-5'-PHOSPHATE IN THE STRUCTURE AND FUNCTION OF PHOSPHORYLASE
• CHAPTER 45. ENZYMATIC STEPS IN THE DEGRADATION OF VITAMIN B6 BY BACTERIA
• CHAPTER 46. CURRENT PROGRESS IN RESEARCH ON BIOLOGICAL PYRIDOXAL CATALYSIS
• SUBJECT INDEX