The Toxicology of Radioactive Substances

Volume 3.59

A. A. Letavet, E. B. Kurlyandskaya

• Publisher: Pergamon
• Year: 2013
• Print ISBN: 9780080117058
• eBook ISBN: 9781483147703
• Topic: Business
• Subtopic: Infrastructure
• Index: Business

The Toxicology of Radioactive Substances, Volume 3: Iron-59 deals with the experimental results of tests conducted at the Radiotoxicology Laboratory of the Institute of Occupational Hygiene and Disease, Academy of Medical Sciences, U.S.S.R. The book focuses on studies made on iron-59, which is widely used in science and technology, such as in the metal industry and in the research of hemoglobin metabolism in the bone marrow and red cells. Other studies show, however, that there is a long-term detrimental effect of intake of iron-59. The text then gives a brief outline of the physical, chemical, and biological properties of iron. Research also shows that the body's reaction to radioactive substances depends on how these are transmitted to the body and on their physicochemical properties. The effect of prolonged administration of radioactive iron on the electrical activity of the cerebral cortex of animals is analyzed, of which, possibly, the nervous system is most affected. The book notes also the changes in the red blood cells during chronic administration of iron-59 in small doses, wherein the hemoglobin levels increased temporarily. Studies of prolonged exposure to radioactive isotopes during pregnancy of the test animals show that there are significant changes in erythropoiesis, associated with iron deficiency. In another study, the prolonged internal administration of radioactive substances showed phasic changes in the height of electrocardiographic waves of the test animals. The text is suitable for physicists, nuclear scientists, doctors of toxicology, and researchers in nuclear medicine.

Table of contents

• Front Cover
• Iron-59
• Copyright Page
• Table of Contents
• CHAPTER 1. TOXICOLOGY OF RADIOACTIVE IRON-59
• CHAPTER 2. DISTRIBUTION AND EXCRETION OF DIFFERENT RADIOACTIVE IRON (59Fe) COMPOUNDS AFTER INTRATRACHEAL INJECTION IN WHITE RATS
• CHAPTER 3. BODY RADIATION DOSE IN RABBITS PRODUCED BY DAILY ORAL ADMINISTRATION OF 59FeCl3, AND SOME DATA ON ACCUMULATION AND EXCRETION OF 59Fe
• CHAPTER 4. THE EFFECT OF PROLONGED ADMINISTRATION OF RADIOACTIVE IRON ON THE ELECTRICAL ACTIVITY OF THE CEREBRAL CORTEX OF RABBITS
• CHAPTER 5. THE EFFECT OF PROLONGED 59Fe ADMINISTRATION ON HAEMOPOIESIS
• CHAPTER 6. CHANGES IN ERYTHROPOIESIS DURING PROLONGED ADMINISTRATION OF 59Fe
• CHAPTER 7. HAEMOPOIESIS AFTER BLOODLOSS IN RABBITS DURING PROLONGED ADMINISTRATION OF 59Fe
• CHAPTER 8. THE EFFECT OF PREGNANCY AND PARTURITION ON HAEMOPOIESIS IN RABBITS DURING PROLONGED 59Fe ADMINISTRATION
• CHAPTER 9. PERIPHERAL BLOOD CHANGES IN WHITE RATS FOLLOWING INTRATRACHEAL INJECTION OF VARIOUS 59Fe COMPOUNDS
• CHAPTER 10. CHANGES IN CARBOHYDRATE METABOLISM AND THE SERUM PROTEIN FRACTIONS DURING PROLONGED ADMINISTRATION OF 59Fe
• CHAPTER 11. THE EFFECT OF PROLONGED INTERNAL ADMINISTRATION OF 59FeCl3 ON THE RABBIT ELECTROCARDIOGRAM
• CHAPTER 12. THE EFFECT ON THE HEARTS OF RABBITS OF PROLONGED INTERNAL IRRADIATION WITH SMALL DOSES OF 59FeCl3
• CHAPTER 13. MORPHOLOGICAL CHANGES IN RATS AFTER INTRATRACHEAL INJECTION OF VARIOUS 59Fe COMPOUNDS
• CHAPTER 14. MORPHOLOGICAL LESIONS IN THE ORGANS OF RABBITS DURING PROLONGED ADMINISTRATION OF 59Fe
• CHAPTER 15. THE EFFECT OF THE CALCIUM DISODIUM SALT OF CYCLOHEXANE-DIAMINOTETRA-ACETIC ACID [CaNa2(CDTA)], THE CALCIUM DISODIUM SALT OF ETHYLENE-DIAMINOTETRA-ACETIC ACID [CaNa2(EDTA)] AND PECTIN ON DISTRIBUTION AND EXCRETION OF 59Fe
• CHAPTER 16. POLYVINYLPYRROLIDONE AND EXPOSURE TO CERTAIN RADIOISOTOPES
• INDEX