Current Trends in Organic Synthesis

Proceedings of the Fourth International Conference on Organic Synthesis, Tokyo, Japan, 22-27 August 1982

Hitosi Nozaki

• Publisher: Pergamon
• Year: 2016
• Print ISBN:
  9780080292175
• eBook ISBN:
  9781483279121
• Topic: Physical Sciences
• Subtopic: Chemistry
• Index: Chemistry

Current Trends in Organic Synthesis is a collection of papers presented at the Fourth International Conference on Organic Synthesis, held in Tokyo, Japan on August 22-27, 1982. This conference brings together the significant achievements in the diversified frontier fields of organic synthesis. This book is composed of 33 chapters. The first chapters focus on the synthesis of biologically active natural compounds, including metabolites of arachidonic acid, erythromycin A, verrucarins, steroids, anthracyclines, terpenes, yeast alanine t-RNA, beta-lactam antibiotics, and palitoxin. Other chapters deal with the central problems in stereoselective and chiral synthesis, as well as processes of high degree of stereochemical control and asymmetric induction. These chapters also describe chiral pool synthesis by means of carbohydrate precursors. This book also examines the methodologies in organic synthesis using reagents with boron, aluminum, transition metals, silicon, phosphorus, and sulfur. The remaining chapters are devoted to reactions involving radical initiated ring closure, small ring hydrogenolysis, annulene synthesis, vicarious nucleophilic substitution of aromatic hydrogen, and dichlorine monoxide mediated powerful chlorination. This book is of value to organic chemists and allied scientists.

Table of contents

• Front Cover
• Current Trends in Organic Synthesis
• Copyright Page
• Table of Contents
• Organizing Committee
• PREFACE
• ACKNOWLEDGEMENTS
• CHAPTER 1. LEUKOTRIENES AND OTHER EICOSANOIDS: SYNTHESES AND SYNTHETIC METHODS
• CHAPTER 2. SYNTHETIC APPROACHES TO BIOLOGICALLY ACTIVE PROSTACYCLIN-ANALOGUES
• CHAPTER 3. THE ALDOL CONDENSATION AS A TOOL FOR STEREOSELECTIVE ORGANIC SYNTHESIS
• CHAPTER 4. STUDIES DIRECTED TOWARDS VERRUCARINS: A SYNTHESIS OF VERRUGAROL. AN APPROACH TO VERRUCARIN A
• CHAPTER 5. NEW APPROACHES TO THE TOTAL SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS
• CHAPTER 6. STUDIES DIRECTED TOWARDS THE CHEMICAL SYNTHESIS OF YEAST ALANINE tRNA
• CHAPTER 7. SYNTHETIC ASPECTS OF 1-OXACEPHEM ANTIBIOTICS
• CHAPTER 8. STUDIES RELATED TO BETA-LACTAM COMPOUNDS
• CHAPTER 9. STEREOCHEMISTRY OF PALYTOXIN
• CHAPTER 10. DIASTEREO- AND ENANTIO-SELECTIVE CYCLOADDITION AND ENE REACTIONS IN ORGANIC SYNTHESIS
• CHAPTER 11. Hydrazones, Formamides, Allylamines and Aminonitriles
• CHAPTER 12. A NEW METHODOLOGY FOR THE GENERATION OF o-QUINODIMETHANES AND RELATED INTERMEDIATES — AN APPROACH TO ASYMMETRIC SYNTHESIS OF POLYCYCLES
• CHAPTER 13. ASYMMETRIC SYNTHESIS USINGE NANTIOMERICALLY PURE SULFOXIDES
• CHAPTER 14. STEREOCONTROL VIA CYCLIZATION REACTIONS
• CHAPTER 15. STEREOCONTROLLED SYNTHESIS OF 25S,26-DIHYDROXY- AND lα,25S,26-TRIHYDROXYCHOLECALCIFEROL SIDE CHAINS
• CHAPTER 16. CARBOHYDRATE DERIVATIVES IN THE ASYMMETRIC SYNTHESIS OF NATURAL PRODUCTS
• CHAPTER 17. CARBOHYDRATES AS "CHIRAL TEMPLATES" IN ORGANIC SYNTHESIS — TARGET: BOROMYCIN
• CHAPTER 18. STEREOCHEMICAL CONTROL IN MACROCYCLE SYNTHESIS
• CHAPTER 19. STEREOCHEMICAL CONTROL IN MACROCYCLIC COMPOUNDS
• CHAPTER 20. NEW HYDROBORATING AGENTS
• CHAPTER 21. PALLADIUM- OR NICKEL-CATALYZED CROSS COUPLING INVOLVING PROXIMALLY HETEROFUNCTIONAL REAGENTS
• CHAPTER 22. SELECTIVE REACTIONS USING ORGANOALUMINUM REAGENTS
• CHAPTER 23. NEW ACCESS TO CONJUGATED DIENES VIA CARBOCUPRATION OF ALKYNES
• CHAPTER 24. QUINONE SYNTHESIS WITH ORGANOMETALLIC REAGENTS
• CHAPTER 25. ORGANO-SILICON MEDIATED SYNTHETIC REACTIONS
• CHAPTER 26. TRIMETHYLSILANOL AS A LEAVING GROUP IN PREPARATIVE ORGANIC CHEMISTRY
• CHAPTER 27. REACTION OF SILYL ENOL ETHERS WITH GARBENES AND CARBENOIDS. NEW SYNTHESES OF VARIOUS CARBONYL COMPOUNDS
• CHAPTER 28. A NEW SYNTHETIC APPROACH TO 1,4-DICARBONYL SYSTEMS AND FUNCTIONALIZED CYCLOPENTENONES BASED ON THE HORNER-WITTIG REACTION OF PHOSPHONATES CONTAINING SULFUR
• CHAPTER 29. VINYL AND BETA-ALKOXY RADICALS IN ORGANIC SYNTHESIS
• CHAPTER 30. SELECTIVE HYDROGENOLYSIS OF C-C BONDS IN SMALL RING COMPOUNDS
• CHAPTER 31. RECENT SYNTHETIC DEVELOPMENTS IN ANNULENE CHEMISTRY
• CHAPTER 32. VICARIOUS NUCLEOPHILIC SUBSTITUTION OF HYDROGEN. A NEW METHOD OF NUCLEOPHILIC ALKYLATION OF NITROARENES
• CHAPTER 33. DICHLORINE MONOXIDE. A POWERFUL AND SELECTIVE CHLORINATING REAGENT
• INDEX