
Structure–Function Relationships of Proteolytic Enzymes
Proceedings of the International Symposium, Copenhagen June 16-18, 1969, No. 37 in the Series of the International Union of Biochemistry Sponsored Symposia
- 310 pages
- English
- PDF
- Available on iOS & Android
Structure–Function Relationships of Proteolytic Enzymes
Proceedings of the International Symposium, Copenhagen June 16-18, 1969, No. 37 in the Series of the International Union of Biochemistry Sponsored Symposia
About this book
Structure–Function Relationships of Proteolytic Enzymes provides information pertinent to the fundamental aspects of proteolytic enzymes. This book presents the historical role of proteolytic enzyme as a group in protein and enzyme chemistry. Organized into 23 chapters, this book begins with an overview of the results obtained from investigation on the chymotrypsinogens of porcine origin. This text then examines the differences of amino acid sequence between chymotrypsin, trypsin, and elastase that affect the substrate binding site, which reflect the specificity differences between these enzymes. Other chapters consider the kinetic parameters related to the trypsin-catalyzed hydrolysis of several model peptides. This book discusses as well the acetylation of trypsin, which result in functional consequences varying from complete inactivation to promotion of activity. The final chapter deals with the physical properties of stem bromelain in comparison with the data for three other sulfhydryl proteases of plant origin. This book is a valuable resource for enzymologists, microbiologists, and biochemists.
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Table of contents
- Front Cover
- Structure-Function Relationships of Proteolytic Enzymes
- Copyright Page
- Table of Contents
- Preface
- List of Participants
- Foreword
- Chapter 1. On the Three Chymotrypsinogens of Porcine Pancreas
- Chapter 2. Chymotrypsin: Tertiary Structure and Enzymatic Activity
- Chapter 3. The Role of Carboxylates and Phenol Side-chains in the Activity and Conformation of Trypsinogen, Trypsin, Chymotrypsinogen, and Chymotrypsin
- Chapter 4. Chemical Modifications of Bovine Trypsinogen and Trypsin
- Chapter 5. The Specificity Site of Trypsin
- Chapter 6. Structure and Mechanism of Action of a Pancreatic Trypsin Inhibitor
- Chapter 7. The Chemistry of the Reactive Site of Soybean Trypsin Inhibitor
- Chapter 8. Structural Aspects of Interaction of Trypsin with Macromolecular Inhibitors
- Chapter 9. Homology and Phylogeny of Proteolytic Enzymes
- Chapter 10. Structural Aspects of Thrombin and Prothrombin
- Chapter 11. Cobalt Proteases: Implications of Absorption and Circular Dichroism Spectra for Catalysis
- Chapter 12. Some Structure-Function Relationships in the Subtilisins
- Chapter 13. Subtilisin BPN': Tertiary Structure and Inhibitor Binding
- Chapter 14. Subtilisin: Stability Properties and Secondary Binding Sites
- Chapter 15. Aminopeptidases from Thermophilic Microorganisms
- Chapter 16. A Synthetic Approach to the Study of Microenvironmental Effects on Enzyme Action
- Chapter 17. Specificity and Mechanism of Pepsin Action
- Chapter 18. Towards a Mechanism for Pepsin
- Chapter 19. Chemical Studies on Purified Pepsin
- Chapter 20. Porcine Pepsinogen and Pepsin
- Chapter 21. The Three-Dimensional Structure of Papain
- Chapter 22. Streptococcal Proteinase
- Chapter 23. Structure and Function of Stem Bromelain