Ureases

Functions, Classes, and Applications

Rodrigo Ligabu Braun, Celia Regina R Da S Carlini, Rodrigo Ligabu Braun, Celia Regina R Da S Carlini

• Publisher: Academic Press
• Year: 2024
• Print ISBN:
  9780323918008
• eBook ISBN:
  9780323972000
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Ureases: Foundations, Classes, and Applications provides a thorough, practical analysis of ureases—enzymes of growing relevance across a range of biotechnological applications and drug discovery. Unique in many aspects, ureases are one of the few enzymes to have nickel in their active sites. Ureases covers all aspects of this enzymatic class. Starting with foundational overview, the book discusses historical urease research and the current state, from basic biochemistry to the use of ureases as hallmarks in enzymology, crystallography, and bioinorganic chemistry. The different classes of ureases, structurally diverse but chemically equivalent, are individually discussed. The multi-protein, multi-step activation of ureases (with chemical modification of residues, transport, and transfer of nickel ions) are examined in-depth, along with the catalytic mechanisms of ureolysis and its inhibitors. The final two sections of the book address multiple applications of ureases in health and biotechnology, respectively, going from gastric ulcer treatment to architectural uses in buildings and engineering. Future applications and next steps in research are also considered. - Considers fundamental aspects of urease biochemistry, ureolysis and urease inhibitors - Discusses urease research across a range of applications, from drug discovery to biosensors, water purification, architecture and the food industry - Features chapter contributions from international leaders in the field

Table of contents

• Cover
• Title page
• Table of Contents
• Copyright
• Contents
• List of contributors
• About the editors
• Preface
• List of Illustrations
• List of Tables
• 1 : Ureases: an overview
• 2 : Historical hallmarks in urease study
• 3 : Genetics of plant urease, the enzyme that keeps surprising us
• 4 : Microbial ureases
• 5 : Plant ureases: biochemistry, structure, physiological functions, role of urease inhibitors, and urease applications in industry
• 6 : Jack bean urease
• 7 : Fungal ureases
• 8 : Urease: structure, function, catalysis, and inhibition
• 9 : Inhibition of ureases: studies and applications
• 10 : Nonenzymatic properties of ureases
• 11 : Ureases as drug targets in urinary tract infections
• 12 : Ureases as drug targets in fungal infections
• 13 : Reaching food security: harnessing urease inhibitors to meet the challenges of growing global population
• 14 : Ureases as pesticides
• 15 : Ureases in the beverage industry
• 16 : Versatility of ureases: many uses for biotechnological and medical applications
• Index
• A