Advancement of Phenolic Acids in Drug Discovery

Fundamentals and Applications

Naresh Kumar, Nidhi Goel, Jesus Simal Gandara, Naresh Kumar, Nidhi Goel, Jesus Simal Gandara

• Publisher: Academic Press
• Year: 2024
• Print ISBN:
  9780443185380
• eBook ISBN:
  9780443185397
• Topic: Medicine
• Subtopic: Biochemistry in Medicine

Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book's final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids. - Highlights fundamental concepts with advanced exploration of phenolic acids - Provides in-depth coverage on the design and development of novel drugs from natural phenolic acids - Reviews the changing role of phenolic acids

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• List of contributors
• Chapter 1. Phenolic acids: a brief overview
• Chapter 2. Sources and extraction methods of phenolic acids
• Chapter 3. Role of phenolic acids in plant system
• Chapter 4A. Antioxidant methods, in vitro and in vivo studies of phenolic acids
• Chapter 4B. Phenolic acids as potent antioxidant agents
• Chapter 5. Progressive approach of phenolic acids toward the advancement of antimicrobial drugs
• Chapter 6. Promising role of phenolic acids as antimalarial and antiviral drugs
• Chapter 7. Development of phenolic acids-based system as anticancer drugs
• Chapter 8. Utility of phenolic acids in neurological disorders
• Chapter 9. Role of Aronia’s phenolic acids in the treatment of diabetes mellitus
• Chapter 10. Role of phenolic acids in treatment and prevention of cardiovascular diseases
• Chapter 11. Development of phenolic acid–based nanoparticles and nanomedicines
• Chapter 12. Valorization of phenolic compounds delivery through lactic acid fermentation of fruit and vegetable juices: innovations, challenges, and gaps
• Chapter 13. Development of metal–phenolic acid network for biomedical usages
• Chapter 14. Grand challenges and opportunities for phenolic acids
• Index