The Neuropathogenesis of Mood Disorders

A Review on Neuropsychiatric Disorders

Anthony John McClelland

• Publisher: De Gruyter
• Year: 2024
• Print ISBN: 9783111432854
• eBook ISBN: 9783111433325
• Edition: 1
• Topic: Medicine
• Subtopic: Psychiatry & Mental Health

Neurology does not include study of the limbic system as this is regarded as more relevant to psychiatry. Paradoxically, psychiatrists receive no education on the anatomy, physiology or neuropathology of the limbic system either during their specialist training programs internationally. Their focus is purely on the diagnosis and treatment of mental illness. Thus, they are unique among the medical specialities in the 21 st century. The morbidity and mortality of the many millions of patients with mood disorders has remained unchanged for multiple decades, as opposed to the progressive advances made in all other medical specialities. This is a travesty and a tragedy for a medical specialist discipline. Accordingly, using advances in immunology, radiology and my own personal insights, and after considerable research, I have discovered the complex neuropathogenesis of mood disorders and how to substantially improve the treatment regimen in order to substantially improve patient outcomes. A detailed, comprehensive description of the anatomy, physiology, the neuropathology of the limbic system and the underlying etiology of mood disorders are described in this book. It is likely that a team approach using a psychiatrist and an immunologist will be required for patients with bipolar 2 and treatment resistant depression as the use of biological agents are complex and require considerable experience.

Table of contents

• Title Page
• Copyright
• Contents
• Introduction
• Chapter 1 The Unusual Approach of Psychiatric Specialist Training in Relationship to All Other Specialist Disciplines
• Chapter 2 The Current Inadequacies of Psychiatry as an Evolving Specialty in the Twenty-First Century
• Chapter 3 A Brief Overview of the Anatomy of the Brain
• Chapter 4 A Detailed Description of the Anatomy of the Limbic System and Its Connections
• Chapter 5 Diencephalon
• Chapter 6 The Hypothalamus
• Chapter 7 The Gross Anatomy of the Brain
• Chapter 8 More Comprehensive Discussion of the Neuropathophysiology of the Limbic System
• Chapter 9 Cytokines and Other Proinflammatory Agents
• Chapter 10 Treatment of the Chronic Inflammatory State of Mood Disorders
• Chapter 11 Risks and Complications of TNF-Alpha Inhibitors
• Chapter 12 IL-6 and Other Proinflammatory Cytokines and Biochemical Agents Are Involved in the Autoimmune Inflammatory Response
• Chapter 13 Nonbiological Therapeutic Options
• Chapter 14 Drug Combinations with MTX in Rheumatoid Arthritis
• Chapter 15 Crohn’s Disease and Ulcerative Colitis
• Chapter 16 Description of Multiple Other Immunosuppressive Drugs
• Chapter 17 Hydroxychloroqine
• Chapter 18 Rituximab
• Chapter 19 IL-6 Inhibitors
• Chapter 20 Azathioprine
• Chapter 21 Cyclophosphamide
• Chapter 22 Abatacept
• Chapter 23 JAK Inhibitors
• Chapter 24 Other Agents
• Chapter 25 Chelators
• Chapter 26 Glucocorticoids
• Chapter 27 The Pathophysiology of Mood Disorders
• Chapter 28 The Monoaminergic System
• Chapter 29 Biochemical Differences Between Depressed Patients and Healthy Controls
• Chapter 30 Subcortical Limbic Brain Regions
• Chapter 31 The Hypothalamus and the Impact of Mood Disorders
• Chapter 32 The Relevance of Inflammation
• Chapter 33 Perinatal and Postpartum Depression
• Chapter 34 Radiological Imaging in Mood Disorders
• Chapter 35 The Economic Burden of Mood Disorders
• Chapter 36 Overview of the Neuropathogenesis of Mood Disorders
• Chapter 37 The Mood Disorders
• Chapter 38 Psychiatric Specialist Training Time Warp
• Chapter 39 Consequences of the Above
• Index