
- 366 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
About this book
Due to the lack of secure, efficient, and patient-friendly therapies for neurodegenerative disorders, there is a rising demand for innovative approaches. Despite the limited number of nanocarriers approved for human use, they have demonstrated significant potential in preclinical and, in some instances, clinical trials. In alignment with this objective, the chapters of the book are structured to offer a comprehensive overview of recent advancements in medication and dosage form development, specifically emphasizing the nanoparticulate system for targeting the brain. This book aims to furnish readers with a thorough understanding of the clinical application of nanocarrier systems for treating neurodegenerative disorders, encompassing the latest developments, challenges, safety concerns, toxicity issues, regulatory considerations, prospects, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain will find valuable insights in this resource.
Key Features
- Provides a comparative perspective of various nanocarrier systems, therefore facilitating the researcher's selection of appropriate nanoparticulate carriers
- Highlights the related restrictions of brain delivery and current available medicines
- Includes information on the advantages and disadvantages of various biomaterials utilized in the development of nanocarriers for brain targeting
- Emphasizes distinct facets of surface functionalization according to the brain area of interest
- Presents the current advances, preclinical and clinical development, and the future potential of multiple brain-targeting technologies
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Information
Table of contents
- Cover
- Half Title
- Title
- Copyright
- Dedication
- Contents
- Preface
- Acknowledgments
- Contributors
- List of Abbreviations
- Chapter 1 Fundamentals of Blood–Brain Barrier Anatomy and Global Functions
- Chapter 2 Blood–Brain Barrier in Neurodegenerative Disorders
- Chapter 3 Neurodegenerative Disorders: Available Therapies and Their Limitations
- Chapter 4 Challenges in Brain Targeting and Mechanisms of Drug Transfer across the BBB
- Chapter 5 Introduction to Nanomedicine, Nanotechnology, and Nanopharmaceuticals
- Chapter 6 Regulations and Ethics of Nanomedicine and Public Acceptance
- Chapter 7 Safety of Nanoparticles in Medicine
- Chapter 8 Enhancing Brain Drug Delivery with Lipid Nanocarriers for Bioactive Compounds
- Chapter 9 Blood–Brain Barrier Disruption and Nanomedicine in Neurodegenerative Disorders
- Chapter 10 Worldwide Development and Commercialization of Nanomedicine
- Chapter 11 Introduction to Nanoparticles as Potential Carriers for Brain Targeting in Neurodegenerative Disorders
- Chapter 12 Application of Polymeric Nanoparticles in Brain Targeting
- Chapter 13 Lipid-Based Nanocarriers for Brain Delivery of Bioactives in the Treatment of Neurodegenerative Disorders
- Chapter 14 Autophagy and Extracellular Nanovesicles: Communication and Their Therapeutic Application in Neurodegenerative Diseases
- Chapter 15 Mesoporous Silica Nanoparticles as Promising Carriers for Brain Delivery
- Chapter 16 Potential of Dendrimers as Nanocarriers for Brain Drug Delivery
- Chapter 17 Surface-Active Ligands for Brain Targeting
- Chapter 18 Nanocarriers for Brain Delivery: Safety, Stability Concerns, and Regulatory Aspects
- Chapter 19 Advancements of Nanocarriers for Brain Targeting and Limitations in Clinical Translation
- Chapter 20 Toward Applicability of Exosomal-ncRNA Precision vs. Nanoparticles to the Brain
- Chapter 21 Current Advancements of Nanocarriers for Neurodegenerative Disorders Linked to Toxoplasmosis
- Chapter 22 Toward Nano-Drug Precision for Neurodegenerative Diseases or Glioma
- Index