- 180 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
About this book
The Evolution of Immunotherapy Against Tumors: An Historical Approach summarizes the literature concerning the development of the theory of immune surveillance against tumors. It discusses the evidence for and against this theory, along with the concept of immunoediting. Finally, current approaches in anti-tumor immunotherapy will be analyzed.The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells develop different strategies to escape immune surveillance. Evidence of immune surveillance comes from both animal models and clinical observations. Mice with a wide variety of immunodeficiencies have a high rate of tumor incidence and are more susceptible to transplanted or chemical carcinogen-induced tumors. Immunosuppressed patients have a high incidence of tumors. However, many patients develop cancer even in the presence of an apparently normal immune system. This indicates that tumor cells can escape immune surveillance.
- Covers the experimental approaches to investigate immunotherapy against tumors
- Provides a comprehensive overview of the pharmacological tools in this field
- Serves as a reference book to researchers in the respective fields and related disciplines
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Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access The Evolution of Immunotherapy Against Tumors by Domenico Ribatti in PDF and/or ePUB format, as well as other popular books in Ciencias biológicas & Inteligencia empresarial. We have over one million books available in our catalogue for you to explore.
Information
Table of contents
- Cover
- Front Matter
- Table of Contents
- Copyright
- Preface
- List of Illustrations
- List of Tables
- 1 : Historical background
- 2 : First evidence
- 3 : Bacillus Calmette–Guerin
- 4 : Immunosurveillance against tumors
- 5 : Immunoediting
- 6 : Inflammation and tumors
- 7 : Therapeutic implications
- 8 : Cytokine therapies
- 9 : Adoptive T cell therapy
- 10 : Tumors express specific antigens
- 11 : Monoclonal antibodies
- 12 : Immunosuppressive effects of VEGF
- 13 : Immunomodulatory effects of angiopoietin, platelet derived growth factor, and hepatocyte growth factor
- 14 : Oncolytic virus therapy
- 15 : Cancer vaccines
- 16 : Engineering of T cells and CAR-T therapy
- 17 : Immune checkpoint inhibitors
- 18 : Co-applying anti-angiogenic and immune checkpoint inhibitors
- 19 : Combination therapies
- 20 : Conclusions
- References
- Index
- A