Nucleoside Triphosphates and their Analogs

Chemistry, Biotechnology, and Biological Applications

Morteza Vaghefi

• Publisher: CRC Press
• Year: 2016
• eBook ISBN: 9781040205457
• Topic: Medicine
• Subtopic: Cell Biology

While adenosine triphosphate (ATP) is described as the universal currency of energy in all living organisms at the cellular level, the actual power lies in its phosphate tail. This book is the first dedicated to the field of nucleoside triphosphate (NTP). Its 13 chapters encompass the contributions of twenty scientists from both academia and industry. It provides collective information on the chemical, physiochemical, and biological properties of both natural and modified NTP and their application in life sciences. Three chapters review families of enzymes that depend on nucleotides for assembling DNA and RNA molecules. The appendix includes supporting NMR data.

Table of contents

• Cover
• Title Page
• Half Title
• Copyright Page
• The Editor
• Contributors
• Introduction
• Table of Contents
• Chapter one Chemical synthesis of nucleoside 5’–triphosphate
• Chapter two Enzymatic synthesis of nucleoside triphosphates
• Chapter three Synthesis and properties of NTP analogs with modified triphosphate chains
• Chapter four Chemical synthesis of oligonucleotide triphosphates
• Chapter five Solid state structures of nucleoside triphosphate metal complexes
• Chapter six DNA polymerases and their interactions with DNA and nucleotides
• Chapter seven RNA polymerases
• Chapter eight Reverse transcriptases
• Chapter nine Base-modified nucleoside triphosphates: chemistry and biological applications
• Chapter ten Nucleoside triphosphate analogs for nonradioactive labeling of nucleic acids
• Chapter eleven Antiviral drugs: triphosphates of nucleoside analogues active as antiviral drugs
• Chapter twelve Other drug applications
• appendix one Phosphorus nuclear magnetic resonance chemical shifts of nucleotide derivatives and some related organophosphorus compounds
• Index