p53 in Breast Cancer

Molecular Mechanisms, Clinical Implications, and Therapeutic Targets

Manzoor Ahmad Mir

• Publisher: CRC Press
• Year: 2024
• eBook ISBN: 9781040261989
• Topic: Medicine
• Subtopic: Immunology

p53 in Breast Cancer: Molecular Mechanisms, Clinical Implications, and Therapeutic Targets comprehensively reviews the role of p53 in breast cancer development, progression, and treatment. It explores the multifaceted functions of p53, from its fundamental connection to breast cancer and pathway mechanisms to its influence on cancer metabolism and the impact of mutational alterations. The initial chapters discuss the complex landscape of p53's involvement in cancer metabolism, the ramifications of its mutations, and its crucial role as a tumor suppressor. The subsequent chapters review the regulatory functions of p53 in cell death, DNA repair, genomic stability, and cell cycle dynamics, highlighting its interactions with transcription factors, DNA repair enzymes, and family members p63 and p73. It further reviews the regulation of mutant p53 via post-translational modifications and delves into the approaches to combat mutated p53, highlighting targeted therapies and efforts to overcome chemoresistance. The chapters also address the role of p53 biomarkers in diagnosis and prognosis, the optimization of treatment responses, and the impact of nutrition on p53 activity. This book is an important resource for oncology and molecular biology researchers.

Key Features

• Provides a thorough examination of the p53 gene and its crucial involvement in breast cancer.
• Explores the critical implications of mutational alterations in p53 on the development and progression of breast cancer.
• Examines the role of p53 in managing apoptosis and contributing to DNA repair and genomic stability.
• Discusses the complex interactions of p53 with transcription factors, DNA repair enzymes, p63, and p73.
• Highlights the role of p53 as a biomarker in diagnosing and predicting breast cancer prognosis.

Table of contents

• Cover
• Half-Title
• Title
• Copyright
• Contents
• Introduction
• Preface
• Acknowledgments
• About the Editor
• List of Contributors
• Chapter 1 Role of p53 in Cancer Metabolism
• Chapter 2 Exploring the Intricacies of p53 and Its Connection to Breast Cancer
• Chapter 3 p53 Pathways in the Progression of Breast Cancer
• Chapter 4 Mutational Alterations in p53: Their Impact on the Development of Breast Cancer
• Chapter 5 p53 and Cell Death Regulation: Managing Apoptosis in Breast Cancer
• Chapter 6 The Contribution of p53 in DNA Repair and Genomic Stability in Breast Cancer
• Chapter 7 Interaction of Mutant p53 with Transcription Factors and DNA Repair Enzymes
• Chapter 8 p53 Control of Cell Cycle Dynamics in Breast Cancer: Maintaining a Balance between Arrest and Proliferation
• Chapter 9 The Complex Interplay between Mutant p53, p63, and p73 and Their Effects on the Cellular Process
• Chapter 10 Role of Post-Translational Modifications in the Regulation of Mutant p53
• Chapter 11 Genetic Alterations Affecting p53 and Emerging Perspectives on Epigenetic Control of p53 in Breast Cancer
• Chapter 12 Targeted Therapies against Mutated p53 in Breast Cancer
• Chapter 13 The Role of the Mevalonate Pathway in Cancer Progression with Mutant p53
• Chapter 14 Interactions and Implications of p53 in Hormonal Signaling Pathways in Breast Cancer
• Chapter 15 p53 as a Diagnostic Biomarker in Breast Cancer
• Chapter 16 The Impact of Nutrition on p53 Activity: Implications for Preventing and Treating Breast Cancer
• Chapter 17 The Interplay between p53 and the Tumor Microenvironment in Progressing Breast Cancer
• Chapter 18 Current State and Future Avenues of p53 Gene Therapy in Breast Cancer
• Chapter 19 Insights from Genetic Studies: The Role of p53 in Hereditary Breast Cancer Syndrome
• Chapter 20 Bridging Bench to Bedside in Breast Cancer Therapy: Translational Insights into p53
• Index