Degradation of Bioactive Substances

Physiology and Pathophysiology

Jens H. Henriksen

• Publisher: CRC Press
• Year: 2024
• eBook ISBN:
  9781040280546
• Topic: Medicine
• Subtopic: Biochemistry in Medicine

Intended primarily for researchers working with bioactive substances such as hormones, neurotransmitters, growth factors, and connective tissue makers, this book discusses the principles of degradation in major groups of bioactive materials with respect to physiology, location, and regulation. Peptidases; receptor-mediated endocytosis; organ extraction and clearance; and the degradation of specific proteins, peptides, amines, steroids, and polysaccharoides are featured. Pathophysiology and its role in diagnostics and disease are considered throughout the book, in addition to updates of recent literature and substantial new information on physiology and pathophysiology of degradation of bioactive material. No special mathematical or kinetic background is necessary to read this book because the mathematic and kinetic concepts are facilitated through the presentation of fundamental and more advanced principles. Furthermore, illustrations and tables are provided to facilitate the understanding of the dynamic aspects of degradation processes. Degradation of Bioactive Substances: Physiology and Pathophysiology is the first comprehensive work describing the degradation of bioactive material, including information not found in biochemical textbooks on internal metabolism or pharmacokinetic textbooks on drug metabolism.

Table of contents

• Cover
• Title
• Copyright
• Dedication
• Table of Contents
• Chapter 1 Introduction
• Chapter 2 Kinetics of Whole-Body and Organ Degradation
• Chapter 3 Kinetics of Elimination from the Blood: Principles and Procedures
• Chapter 4 Peptidases Involved in the Metabolism of Bioactive Peptides
• Chapter 5 Receptor-Mediated Endocytosis and Degradation of Polypeptide Hormones, Growth Factors, and Neuropeptides
• Chapter 6 Degradation of Circulating Renin and Angiotensin
• Chapter 7 Processing and Clearance of Atrial Natriuretic Factors (ANF)
• Chapter 8 Degradation of Gastric Peptides: Metabolism of the Gastrins
• Chapter 9 Degradation of Circulating Intestinal Peptides: Metabolism of Substance P and Vasoactive Intestinal Polypeptide
• Chapter 10 Degradation of Glucagons.
• Chapter 11 Degradation of Pancreatic Polypeptide — A Peptide Hormone with a Globular Structure in Aqueous Solution
• Chapter 12 Degradation of Neuropeptides
• Chapter 13 Degradation of Neurohyophysial Peptides
• Chapter 14 Activation and Degradation of Complement: Physiology and Pathophysiology
• Chapter 15 Degradation of Circulating Connective Tissue Components
• Chapter 16 Catabolism of Hyaluronan
• Chapter 17 Degradation of Circulating Cortical Steroids
• Chapter 18 Degradation of Endogenous Catecholamines
• Index