
- 224 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
The Immunogenetics of Autoimmune Diseases, Volume I
About this book
Many developments in immunology have occurred over the past 10 years that give us a better understanding of the immune system and its dysfunctions. Refined mapping of the major histocompatibility complex MHC; elucidation of its gene structure and polymorphism, as well as the molecular basis of MHC restriction; the arrangement, expression, and regulation of immunoglobulins; definition of the structure of the T cell receptor and organization of its genes; and the characterization of soluble factors involved in cell/cell interactions and cloning of their genes are among the major accomplishments. Volumes I and II build on these developments in basic immunology to introduce animal models of various diseases, corresponding human studies, and the genetic analysis of autoimmune traits at the patient population level. The book will be a tremendous asset to immunologists, geneticists, and physicians in various areas of clinical subspecialties.
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Table of contents
- Cover
- Title
- Copyright
- The Editor
- Contributors, Volume I
- Outline, Volume II
- Table of Contents, Volume I
- Chapter 1 Development of the Antibody Repertoire
- Chapter 2 T Cell Antigen Receptors
- Chapter 3 A Primer on Antigen Processing and Presentation
- Chapter 4 The T Cell Circuits-their Defects in Autoimmunity
- Chapter 5 Hormones, Genes, and Autoimmunity
- Chapter 6 Regulatory Idiotypes: Roles in Autoregulation and Autoimmunity
- Chapter 7 Natural Autoantibodies in Regulation of Immune Homeostasis and Autoimmune Diseases
- Chapter 8 T Cell Receptor and Autoimmune Disease
- Chapter 9 Virus-Induced Autoimmunity
- Chapter 10 MHC Molecule Expression in Nonlymphoid tissue: Implication for Autoimmunity
- Chapter 11 Experimental Regulation of Autoimmune Disease
- Chapter 12 Major Histocompatibility Complex Allele-Disease Associations in the Light of Extended Haplotypes
- Chapter 13 Theoretical Modelling and Population Epidemiology of Complex Genetic Diseases
- Index