Polymers for Oral Drug Delivery Technologies

Anilkumar Parambath

• Publisher: Woodhead Publishing
• Year: 2024
• eBook ISBN:
  9780443137754
• Topic: Medicine
• Subtopic: Pharmaceutical, Biotechnology & Healthcare Industry

Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery?of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract. - Provides a comprehensive update on the state of polymer technology for oral drug delivery, bringing the reader up-to-speed via a single reference - Covers a range of polymer technology types, including capsule forming polymers, matrix formers, functional polymer coatings, and more - Contains contributions from global experts spanning academia and industry, offering an interdisciplinary and translational approach to polymers for oral drug delivery

Table of contents

• Cover
• Title page
• Table of Contents
• Copyright
• Contents
• List of contributors
• Preface
• List of Illustrations
• List of Tables
• 1 : Gastrointestinal tract environment and its implications on oral drug delivery
• 2 : Gastrointestinal tract motility and transport
• 3 : Drug absorption and presystemic metabolism and pharmacokinetic modeling
• 4 : In vitro dissolution and predictive release testing
• 5 : Principle characteristics and specification of pharmaceutical polymers
• 6 : Regulatory aspects of polymers used and new polymers for oral medication of gastroretentive dosage forms
• 7 : Classes/types of polymers used in oral delivery (natural, semisynthetic, synthetic), their chemical structure and general functionalities
• 8 : Role of polymers in tableting
• 9 : Capsule-forming polymers
• 10 : Dry and wet granulation
• 11 : Matrix formers
• 12 : Functional polymeric coatings for immediate release dosage forms
• 13 : Polymeric carriers for amorphous solid dispersion
• 14 : Micro/nanoparticles
• 15 : Taste masking polymers
• 16 : Polymers in orally disintegrating tablets and orally dissolving films
• 17 : Additive manufacturing (3d printing)
• 18 : Mucoadhesive forms
• 19 : Gastroretentive dosage forms
• 20 : Polymer blends and additives
• Index
• A