Protein Discovery Technologies

Renata Pasqualini, Wadih Arap

• Publisher: CRC Press
• Year: 2009
• eBook ISBN:
  9781040200766
• Topic: Medicine
• Subtopic: Pharmacology

A True Insider's Guide to the Field - Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications o

Table of contents

• Cover
• Half Title
• Drug Discovery Series
• Title Page
• Copyright Page
• Dedication
• Table of Contents
• Preface
• Editors
• Contributors
• 1 Discovery of Vascular Permeability Factor (VPF, VEGF, VPF/VEGF, VEGF-A165)
• 2 Tumor Necrosis Factor and Its Family Members
• 3 Blood-Brain Barrier Models for Investigating CNS Pathologies
• 4 Identification of Activation of Latent TGFβ as Principal in Vivo Function of Integrin αvβ6
• 5 Purification of Basic Fibroblast Growth Factor by Heparin Affinity
• 6 How It Came to Pass That Interferon Was Used as an Angiogenesis Inhibitor
• 7 Use of Phage Display to Discover Inhibitors of Cell Migration
• 8 Combinatorial Mapping of Vascular Zip Codes by in Vivo Phage Display
• 9 Chasing Elusive Cellular Prion Protein Receptor
• 10 Discovery of Molecular Chaperone GRP78 and GRP94 Inducible by Endoplasmic Reticulum Stress
• 11 Origin of Sphingomyelin Pathway
• 12 Endotoxin-Induced Myocarditis A New Pathophysiological Entity in Systemic Inflammatory Response Syndrome
• 13 Discovery of DOCK180 Superfamily of Exchange Factors
• 14 Discovery of Extracellular Matrix Degradome as Novel Endogenous Regulators of Angiogenesis and Tumor Growth
• 15 RING Finger Proteins as E3 Ubiquitin Ligases
• 16 Discovery of Chemical Nature of Cross-Links in Collagen A Personal Retrospective
• 17 Discovery of SPARC as Prototype for Matricellular Proteins
• Index