Antimicrobial Peptides

A Roadmap for Accelerating Discovery and Development

Luis H. Reyes, Juan C. Cruz, Gregory R. Wiedman

• Publisher: Elsevier
• Year: 2024
• eBook ISBN: 9780443153945
• Edition: 0
• Topic: Naturwissenschaften
• Subtopic: Biochemie

Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide. Discovering novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation.- Covers computational tools (including emerging artificial intelligence algorithms) and microfluidic systems for discovery and high-throughput screening of AMPs- Discusses the application of bioprocess engineering scale-up approaches for AMPs' production and purification with the aid of process simulation tools and rapid prototyping- Highlights user-centered design and formulation of products with AMPs- Describes the whole pipeline for AMPs production

Table of contents

• Front Cover
• Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development
• Copyright
• Contents
• Contributors
• Introduction-Antimicrobial peptides: From the bench to the bedside
• Section A: Computational approaches
• Section B: Experimental approaches
• Section C: Translational studies
• Index
• Back Cover