The 1993 regulation (Part 503 Rule) governing the land application of biosolids was established to protect public health and the environment from reasonably anticipated adverse effects. Included in the regulation are chemical pollutant limits, operational standards designed to reduce pathogens and the attraction of disease vectors, and management practices. This report from the Board on Environmental Studies and Toxicology evaluates the technical methods and approaches used by EPA to establish those standards and practices, focusing specifically on human health protection. The report examines improvements in risk-assessment practices and advances in the scientific database since promulgation of the regulation, and makes recommendations for addressing public health concerns, uncertainties, and data gaps about the technical basis of the biosolids standards.

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Table of contents
- COVER PAGE
- THE NATIONAL ACADEMIES
- COMMITTEE ON TOXICANTS AND PATHOGENS IN BIOSOLIDS APPLIED TO LAND
- BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY1
- WATER SCIENCE AND TECHNOLOGY BOARD
- OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
- Preface
- Contents
- Abbreviations
- Summary
- 1 Introduction
- 2 Biosolids Management
- 3 Epidemiological Evidence of Health Effects Associated with Biosolids Production and Application
- 4 Advances in Risk Assessment Since the Establishment of the Part 503 Rule
- 5 Evaluation of EPA’s Approach to Setting Chemical Standards
- 6 Evaluation of EPA’s Approach to Setting Pathogen Standards
- 7 Integration of Chemical and Pathogen Risk Assessment
- Glossary
- Appendix A BIOGRAPHICAL INFORMATION ON THE COMMITTEE ON TOXICANTS AND PATHOGENS IN BIOSOLIDS APPLIED TO LAND
- Appendix B PARTICIPANTS AT PUBLIC SESSIONS
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