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About this book
In this first in a proposed series of workshops on regulatory issues in animal care and use, the Institute for Laboratory Animal Research (ILAR) has addressed the existing and proposed requirements for reporting pain and distress in laboratory animals. The Animal Welfare Act, administered by the Animal and Plant Health Inspection Service of the United States Department of Agriculture (USDA), mandates that pain and distress in laboratory animals be minimized. USDA is considering two policy changes with regard to this specific mandate. Firstly, since there has been no functional definition of "e;distress, "e; USDA has prepared such a definition and requested feedback from the scientific community on its usefulness for regulatory and reporting requirements.The second issue concerns the pain and distress categorization scheme for reporting to USDA. Various groups and individuals have questioned the efficacy of the current categories, and specific changes have been proposed by the Humane Society of the United States. USDA is considering these and other potential changes to the existing scheme. Thus, given these potential changes to animal welfare policy, the aim of the ILAR/NIH joint workshop was to provide feedback to the USDA. The speakers were asked to address these two issues as well as to comment upon whether the information contained in the 1992 ILAR report Recognition and Alleviation of Pain and Distress in Laboratory Animals is still useful to investigators in assisting them to comply with regulations. The speakers provided perspectives based on their individual expertise in the areas of science of pain and distress, animal welfare policy, protocol review, and/or as representatives of relevant organizations or institutions. The following proceedings are an edited transcript of their presentations.
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Table of contents
- COVER PAGE
- THE NATIONAL ACADEMIES
- COMMITTEE ON REGULATORY ISSUES IN ANIMAL CARE AND USE
- INSTITUTE FOR LABORATORY ANIMAL RESEARCH COUNCIL
- COMMISSION ON LIFE SCIENCES
- Preface
- Contents
- Introduction
- Pain and Distress: USDA Perspective
- Pain, Distress, and Reporting Requirements: PHS Policy Perspective
- Assessing Pain and Distress: A Veterinary Behavioristās Perspective
- Scientific Issues of Pain and Distress
- The Humane Society of the United States Pain and Distress Initiative
- Pain and Distress Caused by Experimental Proceduresā Is It Time for a Reality Check?
- A View from the Trenches
- AALAS Position Paper on the āRecognition and Alleviation of Pain and Distress in Laboratory Animalsā
- On Regulating Pain and Distress
- An Industrial Perspective
- Corners Still Unswept
- Personal Experiences with Clinical Pain Management, Study Design, Mitigation of Scientific Confounders, and Long-term Gains to the Researchers and Public
- Use of Laboratory Animals in the Postgenome Era
- The History and Histrionics of Pain and Distress in Laboratory Animals
- Panel Discussion with All Speakers
- Appendix A APHIS/USDA Policy 11 and Policy 12
- Appendix 2 Proposed Rulemaking
- Appendix C Glossary of Abbreviations
- Appendix D Meeting Participants
- Appendix E Meeting Agenda
- Appendix F Biographical Sketches of Committee Members