Methodological Challenges in Biomedical HIV Prevention Trials
eBook - ePub

Methodological Challenges in Biomedical HIV Prevention Trials

,
  1. English
  2. ePUB (mobile friendly)
  3. Available on iOS & Android
eBook - ePub

Methodological Challenges in Biomedical HIV Prevention Trials

,

About this book

The number of people infected with HIV or living with AIDS is increasing at unprecedented rates as various scientists, organizations, and institutions search for innovative solutions to combating and preventing the disease. At the request of the Bill & Melinda Gates Foundation, Methodological Challenges in Biomedical HIV Prevention Trials addresses methodological challenges in late-stage nonvaccine biomedical HIV prevention trials with a specific focus on microbicide and pre-exposure prophylaxis trials. This book recommends a number of ways to improve the design, monitoring, and analysis of late-stage clinical trials that evaluate nonvaccine biomedical interventions. The objectives include identifying a beneficial method of intervention, enhancing quantification of the impact, properly assessing the effects of using such an intervention, and reducing biases that can lead to false positive trial results.According to Methodological Challenges in Biomedical HIV Prevention Trials, the need to identify a range of effective, practical, and affordable preventive strategies is critical. Although a large number of promising new HIV prevention strategies and products are currently being tested in late-stage clinical trials, these trials face a myriad of methodological challenges that slow the pace of research and limit the ability to identify and fully evaluate effective biomedical interventions.

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Yes, you can access Methodological Challenges in Biomedical HIV Prevention Trials by in PDF and/or ePUB format. We have over one million books available in our catalogue for you to explore.

Information

Publisher
National Academies Press
Year
2008
eBook ISBN
9780309177795
Edition
0
Topic
Medicine

Table of contents

  1. COVER PAGE
  2. THE NATIONAL ACADEMIES
  3. COMMITTEE ON THE METHODOLOGICAL CHALLENGES IN HIV PREVENTION TRIALS
  4. Reviewers
  5. Contents
  6. Summary
  7. Introduction
  8. 1 The Status and Challenges of Biomedical HIV Prevention Trials
  9. 2 Basic Design Features: Size, Duration, and Type of Trials, and Choice of Control Group
  10. 3 Design Considerations: Risk-Reduction Counseling
  11. 4 Design Considerations: Pregnancy
  12. 5 Design Considerations: Adherence
  13. 6 Design Considerations: Recruitment and Retention
  14. 7 Site Preparedness
  15. 8 Estimating HIV Incidence
  16. 9 Interim Monitoring and Analysis of Results
  17. 10 Alternative Designs
  18. Appendix A Public Committee Meeting Agendas
  19. Appendix B Acronyms
  20. Appendix C Supporting Materials for Chapter 2
  21. Appendix D Methods for Analyzing Adherence
  22. Appendix E Committee Biographies