Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals
eBook - PDF

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

,
  1. 225 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

,

About this book

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures.The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment.It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routes"e;both oral and dermal"e;as well as risk assessors in the government, academe, and private industry.

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Table of contents

  1. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals
  2. Copyright
  3. Preface
  4. Contents
  5. Introduction
  6. Roster National Advisory Committee for Acute Exposure Guideline Levels (NAC/AEGL Committee) for Hazardous Substances
  7. Appendix
  8. Preface
  9. 1. Overview of AEGL Program and NAC/AEGL Committee
  10. 2. Derivation of AEGL Values
  11. 3. Format and Content of Technical Support Documents
  12. 4. Current Administrative Processes and Procedures for the Development of AEGL Values
  13. References
  14. Appendixes