Today's world poses a triple threat to the American population: infectious diseases, contamination of food and water, and bioattacks (biowarfare or bioterrorism). At least 17 countries are producing weapons of mass destruction using viruses, bacteria, or their toxins. AIDS, E. coli contamination, drug-resistant tuberculosis, and virulent flu strains are perhaps the best known of a host of disease threats. What these dangers have in common is the amount of data required to achieve solutions; in some cases, as much as a petabit (1 followed by 15 zeros) of data is required to study large numbers of samples from widespread locations.Firepower in the Lab examines how the nation can combat this triple threat by improving our ability to detect, measure, and monitor harmful biological agents. It explores the potential of today's exciting new laboratory automation and computer technologies as well as the emerging tools of molecular biology--how we can generate and analyze more data quickly and reduce human hands-on involvement, which inevitably introduces errors.The book discusses how to improve and apply technologies such as robotics, laboratory automation, "e;lab-on-a-chip, "e; bioinformatics, and Internet control innovations. It reviews lessons learned from our experience with pandemic flu viruses. It also presents strategies for developing new high-throughput technologies, including how to address the lack of public funding for critical research undertakings.
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Table of contents
- COVER PAGE
- CONTENTS
- PREFACE
- 1 Where the Bucks Stop: A Case for Intermediate-Scale Grants
- 2 Tackling Grand Challenges with Powerful Technologies
- PART I INFECTIOUS DISEASES
- PART II FOOD SUPPLY
- PART III BIOTERRORISM AND BIOWARFARE
- PART IV FURTHER APPLICATIONS AND TECHNOLOGIES
- APPENDIXES
- APPENDIX A CONTRIBUTORS
- APPENDIX B AUTOMATION IN THREAT REDUCTION AND INFECTIOUS DISEASE RESEARCH NEEDS AND NEW DIRECTIONS Agenda of the April 1999 Colloquium
- INDEX
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