Observational Studies in a Learning Health System
eBook - ePub

Observational Studies in a Learning Health System

Workshop Summary

,
  1. English
  2. ePUB (mobile friendly)
  3. Available on iOS & Android
eBook - ePub

Observational Studies in a Learning Health System

Workshop Summary

,

About this book

Clinical research strains to keep up with the rapid and iterative evolution of medical interventions, clinical practice innovation, and the increasing demand for information on the clinical effectiveness of these advancements. In response to the growing availability of archived and real-time digital health data and the opportunities this data provides for research, as well as the increasing number of studies using prospectively collected clinical data, the Institute of Medicine\'s Roundtable on Value & Science-Driven Health Care convened a workshop on Observational Studies in a Learning Health System. Participants, including experts from a wide range of disciplines - clinical researchers, statisticians, biostatisticians, epidemiologists, health care informaticians, health care analytics, research funders, health products industry, clinicians, payers, and regulators - explored leading edge approaches to observational studies, charted a course for the use of the growing health data utility, and identified opportunities to advance progress. Workshop speakers and individual participants strove to identify stakeholder needs and barriers to the broader application of observational studies.Observational Studies in a Learning Health Systemis the summary of the workshop. This report explores the role of observational studies in the generation of evidence to guide clinical and health policy decisions. The report discusses concepts of rigorous observational study design and analysis, emerging statistical methods, and opportunities and challenges of observational studies to complement evidence from experimental methods, treatment heterogeneity, and effectiveness estimates tailored toward individual patients.

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Information

Publisher
National Academies Press
Year
2013
eBook ISBN
9780309290845
Edition
0
Topic
Medicine

Table of contents

  1. COVER PAGE
  2. TITLE PAGE
  3. COPYRIGHT PAGE
  4. TABLE OF CONTENTS
  5. ACRONYMS AND ABBREVIATIONS
  6. 1 INTRODUCTION
  7. 2 ISSUES OVERVIEW FOR OBSERVATIONAL STUDIES IN CLINICAL RESEARCH
  8. 3 ENGAGING THE ISSUE OF BIAS
  9. 4 GENERALIZING RANDOMIZED CLINICAL TRIAL RESULTS TO BROADER POPULATIONS
  10. 5 DETECTING TREATMENT-EFFECT HETEROGENEITY
  11. 6 PREDICTING INDIVIDUAL RESPONSES
  12. 7 STRATEGIES GOING FORWARD
  13. 8 COMMON THEMES FOR PROGRESS
  14. APPENDIXES