Gaucher Disease

Anthony H. Futerman, Ari Zimran

• Publisher: CRC Press
• Year: 2006
• eBook ISBN: 9781040199039
• Topic: Medicina
• Subtopic: Ematologia

In September of 2007 Gaucher Disease received a commendation in the Haematology category of the 2007 British Medical Association Medical Book Competition! Although rare in the general population, Gaucher disease is the most prevalent of the lysosomal storage disorders, making research into this particular orphan disorder an invaluable proto

Table of contents

• Cover Page
• Halftitle Page
• Title Page
• Copyright Page
• Preface
• The Editors
• Contributors
• Contents
• CHAPTER 1: Introduction: Overview and Historical Perspective
• CHAPTER 2: Gaucher Disease: Molecular Biology and Genotype-Phenotype Correlations
• CHAPTER 3: Cell Biology and Biochemistry of Acid ß-Glucosidase: The Gaucher Disease Enzyme
• CHAPTER 4: Saposin C and Other Sphingolipid Activator Proteins
• CHAPTER 5: The X-Ray Structure of Human Acid-ß-Glucosidase: Implications for Second-Generation Enzyme Replacement Therapy
• CHAPTER 6: Cellular Pathology in Gaucher Disease
• CHAPTER 7: The Biochemistry and Cellular Biology of Sphingolipids and Glucosylceramide
• CHAPTER 8: The Development of Enzyme Replacement Therapy for Lysosomal Diseases: Gaucher Disease and Beyond
• CHAPTER 9: Gaucher Disease Animal Models
• CHAPTER 10: Type 1 Gaucher Disease — Clinical Features
• CHAPTER 11: Neuronopathic Gaucher Disease
• CHAPTER 12: Pathologic Anatomy of Gaucher Disease: A Pictorial Essay
• CHAPTER 13: Neuropathological Aspects of Gaucher Disease
• CHAPTER 14: Diagnosis and Laboratory Features
• CHAPTER 15: Imaging in Gaucher Disease, Focusing on Bone Pathology
• CHAPTER 16: Radionuclide Evaluation of Gaucher Disease
• CHAPTER 17: Epidemiology and Screening Policy
• CHAPTER 18: Enzyme Replacement Therapy for Type I Gaucher Disease
• CHAPTER 19: Substrate Reduction Therapy
• CHAPTER 20: Pharmacologic Chaperone Therapy for Lysosomal Diseases
• CHAPTER 21: The Significance of the Blood-Brain Barrier for Gaucher Disease and Other Lysosomal Storage Diseases
• CHAPTER 22: Hematopoietic Stem Cell Transplantation, Stem Cells, and Gene Therapy
• CHAPTER 23: Ethical Concerns in Treating Rare Diseases with Expensive Therapy
• CHAPTER 24: Societal Aspects in Treating Rare Diseases with Expensive Therapy
• CHAPTER 25: Gaucher Disease as a Model for an Orphan Disease: Medical Aspects
• CHAPTER 26: Meeting the Needs of Patients with Gaucher Disease: Pioneering a Sustainable Model for Ultra-Orphan Diseases
• CHAPTER 27: Patients’ Perspective
• CHAPTER 28: Societal Perspective: Comment
• CHAPTER 29: Gaucher Associations Around the World
• Index