Interindividual Variability in Human Drug Metabolism

Gian Maria Pacifici, Olavi Pelkonen

• Publisher: CRC Press
• Year: 2001
• eBook ISBN:
  9781040218525
• Topic: Medicine
• Subtopic: Biochemistry in Medicine

The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of

Table of contents

• Cover
• Title Page
• Copyright Page
• Contents
• Tables
• Figures
• Contributors
• Foreword
• Halftitle Page
• Chapter 1: Genetic factors that cause variability in human drug metabolism
• Chapter 2: Interethnic differences in drug disposition and effects
• Chapter 3: Presystemic binding and/or metabolism equals 1-F and is collectively called “first pass elimination”, or presystemic elimination (E). It follows that
• Chapter 4: Genetic and environmental factors causing variability in psychotropic drug response
• Chapter 5: Interindividual variability in the metabolism of cardiovascular drugs
• Chapter 6: Interindividual variability in the metabolism of anti-epileptic drugs and its clinical implications
• Chapter 7: Variability in the metabolism of levodopa and clinical implications
• Chapter 8: Interindividual variability in the disposition of anti-HIV drugs
• Chapter 9: Predictive modelling of in vivo drug interaction from in vitro data
• Chapter 10: Interindividual variation of P450 enzymes in vitro and its causes
• Chapter 11: Interindividual variability of arylamine N-acetyltransferases
• Chapter 12: Interindividual variation of UDP-glucuronosyltransferases and drug glucuronidation
• Chapter 13: Interindividual variability of methyltransferases
• Chapter 14: Interindividual variability of sulfotransferases
• Chapter 15: Interindividual variability of glutathione transferase expression
• Index