Handbook of Chiral Chemicals

David Ager

• Publisher: CRC Press
• Year: 2005
• eBook ISBN:
  9781040205358
• Topic: Physical Sciences
• Subtopic: Biotechnology

As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook fir

Table of contents

• Cover Page
• Halftitle Page
• Title Page
• Copyright Page
• Contents
• Preface
• The Editor
• Contributors
• Introduction
• Amino Acids
• Microbial Pathway Engineering for Amino Acid Manufacture
• Carbohydrates in Synthesis
• Terpenes: The Expansion of the Chiral Pool
• Resolutions at Large Scale: Case Studies
• New Developments in Crystallization-Induced Resolution
• The Role of c/s-1-Amino-2-Indanol in Resolution Processes
• Asymmetric Oxidations
• 10 Asymmetric Epoxidation of Olefins by Chiral Ketones
• 11 Ozonolysis in the Production of Chiral Fine Chemicals
• 12 Transition Metal Catalyzed Hydrogenations, Isomerizations, and Other Reactions
• 13 Modular, Chiral P-Heterocycles in Asymmetric Catalysis
• 14 Asymmetric Olefin Hydrogenation Using Monodentate BINOL- and Bisphenol-Based Ligands: Phosphonites, Phosphites, and Phosphoramidites
• 15 Asymmetric Catalytic Hydrogenation Reactions with Ferrocene-Based Diphosphine Ligands
• 16 Asymmetric Reduction of Prochiral Ketones Catalyzed by Oxazaborolidines
• 17 c/s-1-Amino-2-Indanol- Derived Ligands in Asymmetric Catalysis
• 18 Enantioselective Hydrogenation of Activated Ketones Using Heterogeneous Pt Catalysts Modified with Cinchona Alkaloids
• 19 Biotransformations: "Green" Processes for the Synthesis of Chiral Fine Chemicals
• 20 Combining Enzyme Discovery and Evolution to Develop Biocatalysts
• 21 One-Pot Synthesis and the Integration of Chemical and Biocatalytic Conversions
• 22 Substitution Reactions
• 23 Industrial Applications of Chiral Auxiliaries
• 24 The Role and Importance of c/s-1-Amino-2-Indanol in Biological Systems and Asymmetric Processes
• 25 Enantiopure Amines by Chirality Transfer Using (R)-Phenylglycine Amide
• 26 Pericyclic Reactions
• 27 Asymmetric Free-Radical Reductions Mediated by Chiral Stannanes, Germanes, and Silanes
• 28 Metathesis Reactions
• 29 Synthesis of Homochiral Compounds: A Small Company's Role4
• 30 Commercial Synthesis of the Antiglaucoma Prostanoid Travoprost
• 31 Synthesis of Large Volume Products