Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration

Sanjoy K. Bhattacharya

• Publisher: Academic Press
• Year: 2025
• Topic: Biological Sciences
• eBook ISBN:
  9780443155819
• Subtopic: Biology
• Index: Biological Sciences

Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome.The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries. - Includes updates on the use of multi-omics datasets for selecting molecules for axon regeneration - Bridges the preclinical and clinical world, from selection of the molecules to outcome leading to IND filing and their use - Includes system level knowledge needed for central nervous system axon and dendrite regeneration, and standardizes the system level biology for axon regeneration - Explores the current state of multi-omics in axon and dendrite regeneration in the optic nerve and its comparison to other CNS regeneration

Table of contents

• Front Cover
• PROTEOMICS, MULTI-OMICS AND SYSTEMS BIOLOGY IN OPTIC NERVE REGENERATION
• PROTEOMICS, MULTI-OMICS AND SYSTEMS BIOLOGY IN OPTIC NERVE REGENERATION
• Copyright
• Dedication
• Contents
• Contributors
• About the editor
• Preface
• Acknowledgments
• I - Historic accounts of neuron regeneration
• II - Reagents for neuron regeneration structural studies
• III - Assessments for functional regeneration
• IV - In vivo models and pharmacological reagents
• V - Systems biology approaches
• VI - Standardization approaches: Application of machine learning and artificial intelligence
• VII - Reconnectivity and new approaches
• VIII - Regeneration applicable in other fields
• IX - Regulatory approval processes and clinical relevant aspects
• X - Protocols and miscellaneous topics
• Index
• Back Cover