Solid-Phase Synthesis

A Practical Guide

Fernando Albericio

• Publisher: CRC Press
• Year: 2000
• eBook ISBN: 9781040211120
• Topic: Medicine
• Subtopic: Chemistry
• Index: Chemistry

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates,

Table of contents

• Cover Page
• Half Title
• Title Page
• Copyright Page
• Foreword
• Preface
• Contents
• Contributors
• Introduction: The Impact of GenomeSequencing on Drug Discovery
• 1. The Solid Support
• 2. Strategy in Solid-Phase Peptide Synthesis
• 3. Amino Acids: Alpha-Amino Protecting Groups
• 4. Side-Chain Protecting Groups
• 5. Solid Supports for the Synthesis of Peptides and Small Molecules
• 6. Coupling Methods: Solid-Phase Formation of Amide and Ester Bonds
• 7. Homodetic Cyclic Peptides
• 8. Disulfide Formation in Synthetic Peptides and Proteins: The State of the Art
• 9. Solid-Phase Convergent Approaches to the Synthesis of Native Peptides and Proteins
• 10. Preparation of Glyco-, Phospho-, and Sulfopeptides
• 11. Oligonucleotide Synthesis
• 12. Synthesis of Oligonucleotide-Peptide Conjugates and Nucleopeptides
• 13. The Chemistry of Peptide Nucleic Acids 549 
• 14. Solid-Phase Synthesis of Oligosaccharides 579 
• 15. Solid-Phase Synthesis of Heterocyclic Compounds from Amino Acids and Linear Peptides
• 16. Solid-Phase Synthesis of Pseudopeptides and Oligomeric Peptide Backbone Mimetics
• 17. Instrumentation
• 18. The Purification of Synthetic Peptides 735 
• 19. Analysis of Synthetic Peptides
• 20. The Chromatographic Analysis of Combinatorial Arrays: Parallel HPLC and HPLC-MS
• Index