Handbook of Adaptive Designs in Pharmaceutical and Clinical Development
eBook - ePub

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

  1. English
  2. ePUB (mobile friendly)
  3. Available on iOS & Android
eBook - ePub

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

About this book

In response to the US FDA's Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the princip

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Yes, you can access Handbook of Adaptive Designs in Pharmaceutical and Clinical Development by Annpey Pong,Shein-Chung Chow in PDF and/or ePUB format, as well as other popular books in Mathematics & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
CRC Press
Year
2016
eBook ISBN
9781040204092
Edition
0
Topic
Mathematics
Subtopic
Pharmacology
Index
Mathematics

Table of contents

  1. Cover
  2. Half title
  3. Title Page
  4. Copyright Page
  5. Table of Contents
  6. Preface
  7. Editors
  8. Contributors
  9. 1 Overview of Adaptive Design Methods in Clinical Trials
  10. 2 Fundamental Theory of Adaptive Designs with Unplanned Design Change in Clinical Trials with Blinded Data
  11. 3 Bayesian Approach for Adaptive Design
  12. 4 The Impact of Protocol Amendments in Adaptive Trial Designs
  13. 5 From Group Sequential to Adaptive Designs
  14. 6 Determining Sample Size for Classical Designs
  15. 7 Sample Size Reestimation Design with Applications in Clinical Trials
  16. 8 Adaptive Interim Analyses in Clinical Trials
  17. 9 Classical Dose-Finding Trial
  18. 10 Improving Dose-Finding: A Philosophic View
  19. 11 Adaptive Dose-Ranging Studies
  20. 12 Seamless Phase I/II Designs
  21. 13 Phase II/III Seamless Designs
  22. 14 Sample Size Estimation/Allocation for Two-Stage Seamless Adaptive Trial Designs
  23. 15 Optimal Response-Adaptive Randomization for Clinical Trials
  24. 16 Hypothesis-Adaptive Design
  25. 17 Treatment Adaptive Allocations in Randomized Clinical Trials: An Overview
  26. 18 Integration of Predictive Biomarker Diagnostics into Clinical Trials for New Drug Development
  27. 19 Clinical Strategy for Study Endpoint Selection
  28. 20 Adaptive Infrastructure
  29. 21 Independent Data Monitoring Committees
  30. 22 Targeted Clinical Trials
  31. 23 Functional Genome-Wide Association Studies of Longitudinal Traits
  32. 24 Adaptive Trial Simulation
  33. 25 Efficiency of Adaptive Designs
  34. 26 Case Studies in Adaptive Design
  35. 27 Good Practices for Adaptive Clinical Trials