- 805 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
Medicinal Chemistry and Drug Development
About this book
Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs, including target identification, which is accomplished by using 30 case studies. This book outlines all the stages of drug development, including the discovery of active compounds, research on the pharmacologicalproperties of molecules, and confirmation of drug targets. The role of the case studies is to show the common factors in the successful development of drugs, thereby showing medicinal chemists how best to explore the scientific pathways when developing new drugs. This makes the book especially relevant for senior university students majoring in pharmaceutical sciences as well as graduate students and researchers.
- Provides unique information on different drug development case studies
- Integrates pharmaceutical knowledgeâmainly medicinal chemistryâwith new drug development thinking
- Describes using case studies, the impact of key events in drug development and on drug efficacy
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Yes, you can access Medicinal Chemistry and Drug Development by Gang Liu in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.
Information
Table of contents
- Front Cover
- Medicinal Chemistry and Drug Development
- Copyright Page
- Contents
- List of contributors
- About the editor
- Preface
- Introduction
- 1 Medicinal chemistry and process development of the type 2 diabetes drug sitagliptin
- 2 The developmental history of insulin pharmaceuticals
- 3 The developmental trajectory of GLP-1 receptor agonists
- 4 Antidiabetic drugs based on sodium-glucose cotransporter 2 inhibitors
- 5 Cholesterol-lowering drug atorvastatin
- 6 Angiotensin II receptor antagonists for treatment of hypertension: the discovery of losartan and its analogs
- 7 Antithrombotic drugâapixaban
- 8 Development of the anticoagulant drug fondaparinux sodium
- 9 Development of the nucleotide antiviral drug sofosbuvir for the hepatitis C virus
- 10 The first HIV-1 integrase inhibitor, raltegravir
- 11 Discovery and development of the human immunodeficiency virus protease inhibitor Saquinavir
- 12 Baloxavir: an antiinfluenza drug with a novel mechanism of action
- 13 Paclitaxel: a natural antitumor agent
- 14 Antitumor drug eribulin
- 15 Targeted protein kinase inhibitor imatinib
- 16 A case study of the irreversible covalent epidermal growth factor receptor (EGFR) inhibitorâafatinib
- 17 Medicinal chemistry and process development of the antibreast cancer drug tamoxifen
- 18 Triazole antifungal drugâfluconazole
- 19 Discovery of the antibacterial drug Linezolid and its synthetic technology research
- 20 Carbapenem antibiotic meropenem
- 21 Antiparasitic drug praziquantel
- 22 A case study on the proton pump inhibitor omeprazole
- 23 The inhibitors of phosphodiesterase type 5A effectively treat erectile dysfunction
- 24 GABAA receptor agonists: discovery of the general anesthetic propofol and its analogs
- 25 The discovery of risperidone: a case of multiple target antipsychotic drug
- 26 A case study on the first-in-class antirenal anemia drug roxadustat
- 27 Function, pharmaceutical, and pharmacological research and development of natural tetracyclic dipyranocoumarin (+)-calan...
- 28 Bisphosphonates: a targeted therapeutic medication for skeletal system
- 29 Celecoxib targets cyclooxygenase in nonsteroidal antiinflammatory drugs
- 30 Case study of antisense oligonucleotides for duchenne muscular dystrophy
- Index
- Back Cover