Molecular Basis of Oxidative Stress

Chemistry, Toxicology, Disease Pathogenesis, Diagnosis, and Therapeutics

Frederick A. Villamena, Henry Jay Forman

• Publisher: Wiley
• Year: 2025
• Print ISBN: 9781119790266
• eBook ISBN: 9781119790273
• Edition: 2
• Topic: Physical Sciences
• Subtopic: Biochemistry

In-depth resource on mechanisms of oxidative stress and damage and the role of free radicals in disease, diagnosis, and therapeutics

Molecular Basis of Oxidative Stress is a comprehensive resource on the molecular and chemical bases of oxidative stress, providing insight on various diseases caused by oxidative stress (cancer, cardiovascular, neurodegenerative) and the role of reactive oxygen species (ROS) in disease pathogenesis along with in-depth knowledge about the mechanisms of oxidative stress and damage, free radical chemistry, and the role of free radicals in disease, diagnosis, and therapeutics.

Thoroughly updated and expanded to reflect advances in the years since its original publication, the Second Edition includes new chapters covering topics like oxidative stress mechanisms, biomarkers, and therapeutic strategies in the management and treatment of diseases. The disease section features 10 new emerging diseases, including kidney and eye diseases and COPD.

This Second Edition also covers developments in the field in the last several years, such as an increase in mortality rate from air pollution and obstructive pulmonary diseases in which exogenous oxidants are initiators.

Written by a team of highly qualified academics, Molecular Basis of Oxidative Stress discusses sample topics including:

• Classification, physico-chemical properties, sources, and detection of reactive species and etiology of COPD from cigarette smoke and pollution
• Oxidative, reductive and indirect non-redox modifications of key biomolecular systems such as lipids, proteins, and DNA by reactive species
• Gene expression of antioxidant defense enzymes, mitochondrial dysfunction and aberrant activation of NOX and cell signaling
• Biomarkers of oxidative stress in neurodegenerative diseases and emerging fields inbiomarker discovery such as cysteinylated albumin and nitroalkene fatty acids

Imparting strong foundational knowledge of redox chemistry, chemistry of oxidative damage and mechanisms of oxidative stress, and oxidative stress-mediated disease pathogenesis, Molecular Basis of Oxidative Stress is an essential reference for both novice and advanced toxicologists, biochemists, and pharmacologists, along with clinical and medical scientists in various fields such as oncology, cardiovascular, andneuroscience.

Table of contents

• Cover
• Title Page
• Copyright Page
• Contents
• List of Contributors
• Preface to Second Edition
• Preface First Edition
• 1 Chemistry of Reactive Species
• 2 Lipid Peroxidation and Nitration
• 3 Protein Posttranslational Modification
• 4 DNA Oxidation
• 5 Cellular Antioxidants and Phase 2 Proteins
• 6 Mitochondrial Dysfunction
• 7 NADPH Oxidases: Structure and Function
• 8 Cell Signaling and Transcription
• 9 Oxidative Stress and Redox Signaling in Carcinogenesis
• 10 Neurodegeneration from Drugs and Aging-Derived Free Radicals
• 11 Cardiac Ischemia and Reperfusion
• 12 Atherosclerosis: Oxidation Hypothesis
• 13 Cystic Fibrosis
• 14 Cigarette Smoking and Air Pollution
• 15 Oxidative Stress in Chronic Obstructive Pulmonary Disease
• 16 Oxidative Stress in the Eye
• 17 The Role of Oxidative Stress in Chronic Kidney Disease (CKD)
• 18 Biomarkers of Oxidative Stress in Neurodegenerative Diseases
• 19 Cysteinylated Albumin as Oxidative Stress Biomarker and Therapeutic Target
• 20 Nitroalkene Fatty Acids: Formation, Metabolism, Reactivity, and Signaling
• 21 Synthetic Antioxidants
• Index
• EULA