Alzheimer’s Disease: New Beginnings

G. Perry, J. Avila, P.I. Moreira, George Perry, Jesús Avila, Paula I. Moreira, Aaron A. Sorensen, Massimo Tabaton

• Publisher: SAGE Publications Ltd
• Year: 2018
• Print ISBN: 9781614998754
• eBook ISBN: 9781614998761
• Edition: 1
• Topic: Biological Sciences
• Subtopic: Neuroscience
• Index: Biological Sciences

Alzheimer's Disease: New Beginnings focuses on the future promise for therapeutic breakthroughs in light of notable clinical trial failures. The volume editors used a combination of scientometric evaluations to determine the most promising new approaches as well as soliciting insights from leaders in each of the major areas of Alzheimer's disease research. By combining these two approaches, they recruited authors from the entire outlook spectrum, from those who feel an elusive breakthrough might still be a few, well-placed tweaks away to those who feel that they are launching entirely new investigative paradigms. These scholars present an open-eyed path forward. Now is the most exciting period in this field as old dogmas make way for new insights, from new approaches to clinical trials, improved biomarker-based diagnostics, population-based studies, prevention, metabolism, to further refinement of the role of inflammation, genetics, tau, and amyloid-ß.

Table of contents

• Title Page
• Preface
• Contents
• Clinical Trials for Disease-Modifying Therapies in Alzheimer's Disease: A Primer, Lessons Learned, and a Blueprint for the Future
• Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment
• Lost in Translation? Finding Our Way To Effective Alzheimer's Disease Therapies
• The End of the Beginning of the Alzheimer's Disease Nightmare: A Devil's Advocate's View
• Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology
• Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease
• Dementia Research: Populations, Progress, Problems, and Predictions
• Three Decades of Dementia Research: Insights from One Small Community of Indomitable Rotterdammers
• Religious Orders Study and Rush Memory and Aging Project
• Prevention Matters: Time for Global Action and Effective Implementation
• Multimodal Neuroimaging in Alzheimer's Disease: Early Diagnosis, Physiopathological Mechanisms, and Impact of Lifestyle
• Preclinical Alzheimer's Disease: Implications for Refinement of the Concept
• Nutritional Intervention as a Preventive Approach for Cognitive-Related Outcomes in Cognitively Healthy Older Adults: A Systematic Review
• The Relationship between Obstructive Sleep Apnea and Alzheimer's Disease
• From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease
• Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: An Invaluable Tool for Clinical Diagnosis and Trial Enrichment
• A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations
• Potential Novel Approaches to Understand the Pathogenesis and Treat Alzheimer's Disease
• Brain Inflammation Connects Cognitive and Non-Cognitive Symptoms in Alzheimer's Disease
• Toward a New Concept of Alzheimer's Disease Models: A Perspective from Neuroinflammation
• Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and in vivo Quantification Using PET
• Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy
• Conquering Alzheimer's Disease by Self Treatment
• Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease
• Iron and Alzheimer's Disease: An Update on Emerging Mechanisms
• Brain Aging and Late-Onset Alzheimer's Disease: A Matter of Increased Amyloid or Reduced Energy?
• Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches
• Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions
• Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer's Disease
• Perspectives on Oxidative Stress in Alzheimer's Disease and Predictions of Future Research Emphases
• Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase
• Findings from the Swedish Study on Familial Alzheimer's Disease Including the APP Swedish Double Mutation
• Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer's Disease
• Our Tau Tales from Normal to Pathological Behavior
• Amyloid-Beta and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies
• New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
• Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation
• The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?
• Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls
• The Amyloid-Beta Oligomer Hypothesis: Beginning of the Third Decade
• Role of Amyloid-Beta and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade
• Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer's Disease
• Underlying Biological Processes in Mild Cognitive Impairment: Amyloidosis Versus Neurodegeneration
• Amyloid-Beta/Drug Interactions from Computer Simulations and Cell-Based Assays