Bradykinin

From Vasodilation to Neuroinflammation

Réjean Couture

• Publisher: Academic Press
• Year: 2025
• Topic: Biological Sciences
• eBook ISBN:
  9780443289088
• Subtopic: Cell Biology
• Index: Biological Sciences

Bradykinin: From Vasodilation to Neuroinflammation, the latest release in the Molecular Mediators in Health and Disease series is a comprehensive guide to the multi-functional peptide bradykinin and its impact across the human body. The early chapters provide an overview of the biosynthesis and metabolism of bradykinin, understanding its receptors and signaling pathways, and the therapeutic value of agonists and antagonists for targeting these. This book explores the role of bradykinin in vascular, renal, and brain function, as well as its influence on various conditions and diseases, including inflammation, pain, cardiovascular disease, renal disease, obesity, ischemic stroke, and infectious diseases, including Covid-19.In addition to its foundational knowledge, the book includes extensive coverage of bradykinin biochemistry and molecular biology. It highlights the therapeutic potential of bradykinin, making it an ideal reference for researchers working in these fields. The book serves as an invaluable resource for understanding the complex roles of bradykinin and its applications in medical research and treatment. - Explores the communication role of bradykinin in both homeostasis and pathologic states - Investigates bradykinin across various conditions, including cardiovascular and renal disease, heart failure, diabetes, and cancer - Discusses bradykinin receptors and their signaling pathways

Table of contents

• Title of Book
• Chapter 1 Introduction to bradykinin
• Chapter 2 Tracing the historical journey: milestones and highlights of bradykinin
• Chapter 3 Kinin receptors and their signaling and regulation
• Chapter 4 Animal models for studying bradykinin receptors
• Chapter 5 Peptide and nonpeptide ligands acting at bradykinin receptors
• Chapter 6 Bradykinin-related peptides and their receptors from nonmammalian vertebrates
• Chapter 7 Bradykinin forming pathways and the pathogenesis of hereditary angioedema
• Chapter 8 Bradykinin in ACEI and other drug-induced angioedema
• Chapter 9 The kinins, a family of bioactive peptides that modulate inflammation
• Chapter 10 Bradykinin in pain
• Chapter 11 Bradykinin in cardiovascular physiology and disease
• Chapter 12 Tissue kallikrein in therapeutic angiogenesis: from basic science to clinical applications
• Chapter 13 Bradykinin in diabetes and obesity
• Chapter 14 Bradykinin in ocular health and diseases
• Chapter 15 Kinin agonists as a means to increase blood–brain barrier permeability of drugs
• Chapter 16 Bradykinin’s role in Alzheimer’s: protection or damage?
• Chapter 17 Bradykinin receptors in neglected parasitic and viral diseases
• Chapter 18 Bradykinin in cancer
• Index