Repeat Amino Acid Sequences in Proteins

Biochemical and Medical Consequences

Vladimir N. Uversky, Munishwar Nath Gupta

• Publisher: CRC Press
• Year: 2025
• Topic: Biological Sciences
• eBook ISBN:
  9781040453766
• Subtopic: Pharmacology
• Index: Biological Sciences

Repeat amino acid sequences are important in protein structure, disorder, function and evolution. Repeats of some amino acids exist in proteomes across species.

This volume highlights:

• Which repeat sequences have pathogenic consequences and why?
• Repeats which lead to surface hydrophobic clusters and their importance
• Role of aromatic amino acid clusters in protein?protein and protein?drug interactions
• Cell?penetrating peptides and Elastin?like peptides
• Unusual phenomenon of fluorescence observed with repeats of some non?aromatic amino acids
• The use of residue cluster classes to represent protein structure and model structure?function relationships.

Table of contents

• Cover Page
• Title Page
• Copyright Page
• Preface
• Contents
• Chapter 1 Pathogenic Role of Repeat Polypeptides in Repeat Expansion Diseases
• Chapter 2 Pathologies Due to PolyQ Sequences
• Chapter 3 Importance of Surface Hydrophobic Clusters in Proteins
• Chapter 4 Residue Cluster Classes in Protein-Protein Interactions
• Chapter 5 Aromatic Clusters in Proteins: Folding, Drug Interactions and Protein-Protein Complexes
• Chapter 6 Cell Penetrating Peptides with Repeat Sequences of Amino Acids
• Chapter 7 Recent Advances and Applications in Self-Assembling Short-Chain Elastin-Like Peptide Analogs
• Chapter 8 Unconventional Fluorescence Properties of Non-aromatic Amino Acids: Material and Biological Applications
• Index