In the vast field of neuroscience, drug discovery targeting the central nervous system (CNS) presents both extraordinary opportunities and complex challenges. Disorders such as Alzheimer's disease, schizophrenia, and epilepsy affect millions worldwide, demanding innovative therapeutic strategies. Yet understanding brain processes and overcoming the blood-brain barrier continue to pose significant hurdles for researchers and developers alike.

Trends in CNS Drug Discovery offers a comprehensive overview of the methodologies, successes, and challenges shaping this critical area of pharmaceutical research. Covering a wide range of key areas, from current therapeutic paradigms to emerging technologies, this state-of-the-art volume brings together expertise from leading scientists and drug developers who address the role of cannabinoids and psychedelics in advancing CNS therapeutics, discuss emerging modalities such as protein degraders and allosteric modulators, examine funding strategies and academic-industrial collaborations, highlight advancements in brain-penetrating cancer treatments and other high-impact areas, and more.

Explores cutting-edge methodologies, including biomarkers, animal models, and brain imaging for CNS drug discovery
Reviews innovative therapies such as combination drugs and prodrugs for improved treatment outcomes
Analyzes challenges in targeting diseases including Alzheimer's and schizophrenia with novel therapeutic strategies
Includes real-world case studies demonstrating achievements and lessons in CNS drug development

A critical reference for academic researchers and industry professionals in medicinal chemistry, pharmaceutical research, and neurobiology, Trends in CNS Drug Discovery is also an ideal resource for graduate-level courses in neuroscience or pharmaceutical sciences.

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Yes, you can access Trends in CNS Drug Discovery by Dario Doller,Kevin J. Hodgetts, János Fischer,Christian Klein,Wayne E. Childers,David P. Rotella in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

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eBook ISBN

Edition

Topic

Medicine

Subtopic

Pharmacology

Cover
Title Page
Copyright
Contents
Series Editors Preface
Preface
Chapter 1 CNS Drug Discovery in “The Century of Biology”
Chapter 2 Advances in Disease Modifying Therapies for Parkinson's Disease
Chapter 3 Psychedelics‐Inspired Drug Discovery
Chapter 4 Epilepsy and Related Seizure Disorders
Chapter 5 Strategies for Neuroprotection in Alzheimer's Disease
Chapter 6 Rigor in Experimental Design in Nonregulated Preclinical Research in Neuroscience Drug Discovery
Chapter 7 Biomarkers in CNS Drug Discovery, Drug Development, and Clinical Implementation
Chapter 8 Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) in CNS Drug Discovery
Chapter 9 Bioanalytical Strategies to De‐risk CNS Drug Discovery for Novel Chemical Modalities
Chapter 10 Discovery of ABBV‐951 (VYALEV™/PRODUODOPA®) for Advanced Parkinson's Disease
Chapter 11 Inducers of Targeted Protein Degradation as Drug Candidates for Neurodegenerative Disorders
Chapter 12 Kinase Inhibitors for the Treatment of Brain Diseases
Chapter 13 An Academic Laboratory's Approach for Discovering CNS‐Active Drug‐Like Small Molecules for the Treatment of SMA
Chapter 14 Medicinal Chemistry “in the System”: A CNS Drug Design Narrative Fit for the Century of Biology
Chapter 15 The Role of Venture Capital in Drug Discovery
Chapter 16 Epilog: CNS Drug Discovery – The Years Ahead
Index
EULA

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