Toxicologic Pathology

An Atlas

Gregory Argentieri, Pritam S. Sahota, Zbigniew W. Wojcinski, Robert H. Spaet, Jerry F. Hardisty

• Publisher: CRC Press
• Year: 2026
• eBook ISBN: 9781040722992
• Topic: Physical Sciences
• Subtopic: Biology

Over the past few decades, there has been an exponential growth of interest in the field of toxicologic pathology, a critical field in safety science, particularly as related to its impact on nonclinical safety in global drug development and care of the environment. Photomicrographic examples of selected nonproliferative and proliferative lesions are necessary to complement the written narratives in textbooks on toxicologic pathology. Toxicologic Pathology: An Atlas fits that need with input provided by top experts in the field. It will become a valuable reference, not only for toxicologic pathologists, but also for a wide variety of nonclinical safety scientists, especially in the pharmaceutical and biotech industries.

This book provides illustrations and descriptions of commonly observed findings in toxicologic pathology (i.e., over 1100 photomicrographic examples). These illustrations add visual context to the terms and descriptions commonly used in the field. The illustrations and accompanying descriptions were prepared and peer reviewed by editors and contributors who are known experts in toxicologic pathology, toxicology, and drug development. The Atlas is designed to be practical, easy to use and written with the hope that it will become a reliable "go-to" reference that will be of interest to students and nonscientists (e.g., individuals serving on animal care and use committees) as a key, single source to understanding terminology and visualizing tissue changes described by toxicologic pathologists.

Table of contents

• Cover Page
• Half Title page
• Title Page
• Copyright Page
• Dedication
• Contents
• Biographies
• Contributors
• Preface
• Acknowledgments
• 1 Introduction to Toxicologic Pathology
• 2 Musculoskeletal System and Teeth
• 3 Cardiovascular System
• 4 Endocrine System
• 5 Digestive Tract
• 6 Hematopoietic System
• 7 Integumentary System
• 8 Liver, Gallbladder, and Exocrine Pancreas
• 9 Lymphoid System
• 10 The Nervous System
• 11 Female Reproductive System
• 12 Male Reproductive System and Mammary Gland
• 13 Respiratory System
• 14 Special Senses
• 15 Urinary System
• 16 Artifacts in Toxicologic Pathology
• 17 Tg.rasH2 Mouse Model
• Index