Chalcones and their Derivatives

From Synthesis to Applications

Mohmmad Younus Wani, Salman Ahmad Khan, Hao Shao, Anish Khan

• Publisher: Elsevier
• Year: 2025
• eBook ISBN:
  9780443301230
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

Chalcone is a highly versatile scaffold with a broad range of applications. Serving as a precursor for various organic molecules and natural flavonoids, it exhibits significant biological activities and unique physical properties, including semiconductor behavior, non-linear optical effects, fluorescence, and electronic characteristics. Chalcones have attracted considerable research interest due to their pharmacological potential and the ease with which their biological activity and other properties can be modified through subtle structural changes along the ?,?-unsaturated backbone. Beyond their medicinal value, chalcones are utilized in the food and cosmetic industries as additives, owing to their UV-protective qualities. Additionally, they serve as chemosensors and probes in analytical applications. The book Chalcones and Their Derivatives: From Synthesis to Applications explores this remarkable molecule, detailing various synthetic methods, its biological significance, and its diverse applications across multiple fields. Serving as both a comprehensive reference for researchers and an essential guide for postgraduate students, this work provides valuable insights into the development and utilization of chalcone-based molecules for a wide array of purposes. - Addresses the lack of in-depth exploration in recent publications, offering a consolidated and holistic perspective on the scaffold's immense potential in various scientific domains - Highlighting the chalcone scaffold's versatility, showcasing its role as a precursor for diverse organic molecules and its contribution to the synthesis of natural flavonoids - Underlines the practical significance of chalcones in industries like food and cosmetics, thanks to their UV protection properties

Table of contents

• Cover image
• Title page
• Copyright
• Contents
• Contributors
• Preface
• CHAPTER 1 Chalcone as a versatile scaffold: An overview
• CHAPTER 2 Naturally occurring chalcones and their biological activities
• CHAPTER 3 Chalcones in drug discovery and medicinal chemistry
• CHAPTER 4 Chalcones: Synthesis strategies and structural modifications
• CHAPTER 5 Exploring the anticancer potential of chalcones: Mechanistic insights and therapeutic prospects
• CHAPTER 6 Chalcones and their derivatives in food industry
• CHAPTER 7 Developing hybrid molecules from chalcones: Bridging structures for enhanced properties
• CHAPTER 8 Chalcone incorporating metal complexes and their biomedical applications
• CHAPTER 9 Chalcones: Structural modification in the synthesis of metal complexes and their applications
• CHAPTER 10 Chalcones and their derivatives as antioxidants: Mechanism and Applications
• CHAPTER 11 Chalcone hybrid molecules: Combining structures for enhanced properties
• CHAPTER 12 Chalcones in drug development: Synthesis, properties, and molecular docking insights into drug targets and biological activity
• CHAPTER 13 Chalcones as molecular probes in chemical biology and bioimaging
• CHAPTER 14 Photophysical behavior of chalcone derivatives: Insights and applications
• CHAPTER 15 Chalcone derivatives in photodynamic therapy: Illuminating new treatment approaches
• CHAPTER 16 The medicinal chemistry of chalcones as potential agents against neglected tropical diseases
• CHAPTER 17 Chalcones and their derivatives as anticancer agents: Mechanisms and applications
• CHAPTER 18 Exploring the antidiabetic potential of chalcones through modulation of PTP1B and PPARγ
• CHAPTER 19 Chalcone-based nanomaterials: Synthesis, characterization, and applications
• CHAPTER 20 Chalcones as fluorescence chemo-sensors for detection of metal ions
• CHAPTER 21 Chalcones as versatile probes for metal ion detection
• CHAPTER 22 Fluorometric and colorimetric sensor properties of chalcone derivatives for detection of metal ions by UV-spectra/emission spectra
• CHAPTER 23 Chalcone-based nanomaterials: Synthesis, characterization, and applications
• CHAPTER 24 Future perspective and emerging trends in chalcone research
• Index