Brain Cancer (Glioblastoma)

The Mathematical Solution

Azhar ul Haque Sario

• Publisher: Azhar Sario Hungary
• Year: 2025
• eBook ISBN: 9783384761101
• Topic: Medicine
• Subtopic: Biotechnology in Medicine

Revolutionizing Glioblastoma Treatment Through Math

Hey there, if you're dealing with brain cancer or just fascinated by how science can crack tough medical puzzles, this book is your guide. It dives into Glioblastoma (GBM), the aggressive brain tumor, but from a fresh angle: math. We start with the basics in the intro, explaining the "Digital Twin"—a virtual model of your tumor that predicts its moves. Chapter 1 covers the Fisher-KPP equation for how tumors spread and grow. It breaks down cell density, diffusion, proliferation, and carrying capacity. We explore the "Go-or-Grow" idea where cells choose to move or multiply. Patient-specific tweaks using MRI scans calibrate your unique model. The invisible tumor edges get mapped out mathematically. Boundaries like the skull are handled with precise conditions. Chapter 2 ups the game with anisotropic diffusion along brain highways, using tensors from DTI imaging. It explains fractional anisotropy as a key biomarker. We model butterfly gliomas crossing brain halves. Numerical solvers tackle the complexity. Chapter 3 uses topological data analysis with Betti numbers to quantify tumor shapes. Persistent homology creates barcodes for heterogeneity. Necrosis shows as loops in the math. AI like TDA-SegUNet improves segmentation. Texture analysis adds radiomics insights. Chapter 4 models angiogenesis with Keller-Segel equations, tracking VEGF and vessel growth. Hypoxia drives it all. We simulate drug resistance like with Bevacizumab. Phase-field models handle multiple tissue types. Chapter 5 dives into poroelasticity for tumor pressure effects. Growth tensors model deformation. Interstitial fluid pressure blocks drugs. We predict herniation risks. Vascular collapse loops back to necrosis. Chapter 6 covers metabolism via the Warburg Effect, with equations for glucose and lactate. Acid invasion clears paths for tumors. Metabolic symbiosis between cells is key. PINNs estimate rates from scans. Chapter 7 uses Darcy's Law for drug delivery via convection-enhanced methods. Tensors guide flow. Backflow issues get simulated. Optimal catheter spots are calculated. Chapter 8 introduces fractional calculus for anomalous diffusion. Memory effects model cell traps. Sub- and super-diffusion fit different tumor parts. MRI helps grade tumors. Chapter 9 optimizes radiation with the Linear-Quadratic model. Alpha/beta ratios guide dosing. Dose painting targets hidden areas. Stem cell resistance is addressed. Chapter 10 plans surgery with Eikonal equations for safe paths. Risk metrics and fast marching methods aid real-time decisions. HIFU ultrasound focuses precisely. Chapter 11 applies evolutionary game theory to drug resistance. Replicator dynamics model cell strategies. Adaptive therapy contains rather than cures. Spatial games show mutant breeding. Chapter 12 uses network control theory to preserve brain function. Controllability metrics predict surgery outcomes. Virtual resections test risks. Energy landscapes explain fatigue. Chapter 13 blends Neural ODEs with physics for hybrid models. AI learns growth laws. PINNs fill in biology gaps. 

What sets this book apart is its laser focus on math as the hero, weaving equations into every aspect of GBM—from invasion to immunity—while others skim the surface with biology alone. Most neuro-oncology books stick to clinical overviews or basic science, missing the predictive power of models like Digital Twins or PINNs that personalize care. Here, you'll get actionable insights, like optimizing radiation or drug delivery, backed by cited research. It bridges gaps left by traditional texts, empowering patients and docs with tools for precision that's often overlooked. No fluff, just math-driven hope where guesswork fails.

This book is independently produced and has no affiliation with any medical board. It uses nominative fair use for referenced concepts.

Table of contents

• Copyright
• Fractional Calculus and Anomalous Diffusion